BACKGROUND: Optical mapping is a widely used experimental tool providing high-resolution recordings of cardiac electrical activity. However, the technique is limited by signal distortion due to photon scattering in the tissue. Computational models of the fluorescence recording are capable of assessing these distortion effects, providing important insight to assist experimental data interpretation. METHODS: We present results from a new panoramic optical mapping model, which is used to assess distortion in ventricular optical mapping signals during pacing and arrhythmogenesis arising from 3-dimensional photon scattering. RESULTS/ CONCLUSIONS: We demonstrate that accurate consideration of wavefront propagation within the complex ventricular structure, along with accurate representation of photon scattering in 3 dimensions, is essential to faithfully assess distortion effects arising during optical mapping. In this article, examined effects include (1) the specific morphology of the optical action potential upstroke during pacing and (2) the shift in the location of epicardial phase singularities obtained from fluorescent maps.
BACKGROUND: Optical mapping is a widely used experimental tool providing high-resolution recordings of cardiac electrical activity. However, the technique is limited by signal distortion due to photon scattering in the tissue. Computational models of the fluorescence recording are capable of assessing these distortion effects, providing important insight to assist experimental data interpretation. METHODS: We present results from a new panoramic optical mapping model, which is used to assess distortion in ventricular optical mapping signals during pacing and arrhythmogenesis arising from 3-dimensional photon scattering. RESULTS/ CONCLUSIONS: We demonstrate that accurate consideration of wavefront propagation within the complex ventricular structure, along with accurate representation of photon scattering in 3 dimensions, is essential to faithfully assess distortion effects arising during optical mapping. In this article, examined effects include (1) the specific morphology of the optical action potential upstroke during pacing and (2) the shift in the location of epicardial phase singularities obtained from fluorescent maps.
Authors: Christopher J Hyatt; Sergey F Mironov; Marcel Wellner; Omer Berenfeld; Alois K Popp; David A Weitz; José Jalife; Arkady M Pertsov Journal: Biophys J Date: 2003-10 Impact factor: 4.033
Authors: Christopher J Hyatt; Sergey F Mironov; Frederick J Vetter; Christian W Zemlin; Arkady M Pertsov Journal: Circ Res Date: 2005-06-30 Impact factor: 17.367
Authors: Martin J Bishop; Blanca Rodriguez; James Eason; Jonathan P Whiteley; Natalia Trayanova; David J Gavaghan Journal: Biophys J Date: 2006-01-27 Impact factor: 4.033
Authors: Richard D Walton; Rebecca M Smith; Bogdan G Mitrea; Edward White; Olivier Bernus; Arkady M Pertsov Journal: Biophys J Date: 2012-01-03 Impact factor: 4.033
Authors: Rachel C Myles; Olivier Bernus; Francis L Burton; Stuart M Cobbe; Godfrey L Smith Journal: Am J Physiol Heart Circ Physiol Date: 2010-10-01 Impact factor: 4.733
Authors: M M Maleckar; M C Woods; V Y Sidorov; M R Holcomb; D N Mashburn; J P Wikswo; N A Trayanova Journal: Am J Physiol Heart Circ Physiol Date: 2008-08-15 Impact factor: 4.733