Literature DB >> 27334789

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.

Hermenegild J Arevalo1, Patrick M Boyle2, Natalia A Trayanova3.   

Abstract

Current understanding of cardiac electrophysiology has been greatly aided by computational work performed using rabbit ventricular models. This article reviews the contributions of multiscale models of rabbit ventricles in understanding cardiac arrhythmia mechanisms. This review will provide an overview of multiscale modeling of the rabbit ventricles. It will then highlight works that provide insights into the role of the conduction system, complex geometric structures, and heterogeneous cellular electrophysiology in diseased and healthy rabbit hearts to the initiation and maintenance of ventricular arrhythmia. Finally, it will provide an overview on the contributions of rabbit ventricular modeling on understanding the mechanisms underlying shock-induced defibrillation.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cardiac electrophysiology; Computational modeling; Defibrillation; Ischemia; Myocardial infarction; Ventricular arrhythmia

Mesh：

Year:  2016        PMID： 27334789      PMCID： PMC4947552          DOI： 10.1016/j.pbiomolbio.2016.06.004

Source DB:  PubMed          Journal:  Prog Biophys Mol Biol        ISSN： 0079-6107            Impact factor:   3.667


  119 in total

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7.  Molecular basis of species-specific expression of repolarizing K+ currents in the heart.

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8.  Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles.

Authors:  Patrick M Boyle; Carolyn J Park; Hermenegild J Arevalo; Edward J Vigmond; Natalia A Trayanova
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9.  Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.

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Journal:  Circ Res       Date:  2007-09-13       Impact factor: 17.367
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  5 in total

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5.  Effect of ventricular myocardium characteristics on the defibrillation threshold.

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