Literature DB >> 17967538

Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents.

Maria Cristina Silva Lourenço1, Felipe Rodrigues Vicente, Maria das Graças Muller de Oliveira Henriques, André Luis Peixoto Candéa, Raoni Schroeder Borges Gonçalves, Thais Cristina M Nogueira, Marcelle de Lima Ferreira, Marcus Vinícius Nora de Souza.   

Abstract

The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.

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Year:  2007        PMID： 17967538     DOI： 10.1016/j.bmcl.2007.09.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Benzyl N-((S)-2-hydr-oxy-1-{N'-[(E)-2-methoxy-benzyl-idene]hydrazinecarbon-yl}eth-yl)carbamate from synchrotron data.

Authors:  Alessandra C Pinheiro; Marcus V N de Souza; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-31

2.  5-{[(E)-2-(4-Iodo-phen-yl)hydrazinyl-idene]meth-yl}thio-phene-2-carbaldehyde.

Authors:  Solange M S V Wardell; Geraldo M de Lima; Edward R T Tiekink; James L Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-09

3.  N-(2,6-Dimethyl-phen-yl)-2-(2-thien-yl)acetamide.

Authors:  Marcelle Ferreira de Lima; Marcus V N de Souza; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-25

4.  Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.

Authors:  Sandeep Thanna; Susan E Knudson; Anna Grzegorzewicz; Sunayana Kapil; Christopher M Goins; Donald R Ronning; Mary Jackson; Richard A Slayden; Steven J Sucheck
Journal:  Org Biomol Chem       Date:  2016-06-02       Impact factor: 3.876

5.  (E)-1-Phenyl-2-({5-[(1E)-(2-phenyl-hydrazin-1-yl-idene)meth-yl]-2-thien-yl}methyl-idene)hydrazine.

Authors:  Geraldo M de Lima; William T A Harrison; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-02-03

6.  N-(4-Bromo-phen-yl)-2-(2-thien-yl)acetamide.

Authors:  Thais C M Nogueira; Marcus V N de Souza; James L Wardell; Solange M S V Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-16

7.  (E)-1-(3-Nitro-phen-yl)-2-({5-[(1E)-2-(3-nitro-phen-yl)hydrazin-1-ylidenemeth-yl]-2-thien-yl}methyl-idene)hydrazine.

Authors:  Geraldo M de Lima; William T A Harrison; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-27

8.  N'-[(1E)-(5-Nitro-furan-2-yl)methyl-idene]thio-phene-2-carbohydrazide: crystal structure and Hirshfeld surface analysis.

Authors:  Laura N F Cardoso; Thais C M Nogueira; James L Wardell; Solange M S V Wardell; Marcus V N de Souza; Mukesh M Jotani; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-06-24
  8 in total

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