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Literature DB >> 17965481

A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.

Masahiro Ogata¹, Jun-ya Ueda, Midori Hoshi, Junko Hashimoto, Takuji Nakashima, Kozue Anzai, Motoki Takagi, Kazuo Shin-ya.

Abstract

A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

Entities: Chemical Disease Species

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Year: 2007 PMID： 17965481 DOI： 10.1038/ja.2007.83

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

9 in total

Review 1. Biosynthesis of fungal indole alkaloids.

Authors: Wei Xu; Diego J Gavia; Yi Tang
Journal: Nat Prod Rep Date: 2014-10 Impact factor: 13.423

2. Asymmetric Total Synthesis of the Indole Diterpene Alkaloid Paspaline.

Authors: Robert J Sharpe; Jeffrey S Johnson
Journal: J Org Chem Date: 2015-10-02 Impact factor: 4.354

3. A global and local desymmetrization approach to the synthesis of steroidal alkaloids: stereocontrolled total synthesis of paspaline.

Authors: Robert J Sharpe; Jeffrey S Johnson
Journal: J Am Chem Soc Date: 2015-04-09 Impact factor: 15.419

4. Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.

Authors: Kyle C Van de Bittner; Rosannah C Cameron; Leyla Y Bustamante; Rudranuj Bundela; Sarah A Kessans; Jan Vorster; Matthew J Nicholson; Emily J Parker
Journal: Medchemcomm Date: 2019-05-27 Impact factor: 3.597

A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.

Review 1. Biosynthesis of fungal indole alkaloids.

2. Asymmetric Total Synthesis of the Indole Diterpene Alkaloid Paspaline.

3. A global and local desymmetrization approach to the synthesis of steroidal alkaloids: stereocontrolled total synthesis of paspaline.

4. Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.

5. A Concise Approach to Paxilline Indole Diterpenes.

6. Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.

7. Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.

8. Aspergillus is monophyletic: Evidence from multiple gene phylogenies and extrolites profiles.

9. Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1.