Literature DB >> 31391888

Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.

Kyle C Van de Bittner1, Rosannah C Cameron1, Leyla Y Bustamante1, Rudranuj Bundela1, Sarah A Kessans2, Jan Vorster3, Matthew J Nicholson1, Emily J Parker1,4.   

Abstract

Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion.

Entities:  

Year:  2019        PMID： 31391888      PMCID： PMC6640557          DOI： 10.1039/c9md00143c

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  30 in total

Review 1.  Nodulisporic acid: its chemistry and biology.

Authors:  Peter T Meinke; McHardy M Smith; Wesley L Shoop
Journal:  Curr Top Med Chem       Date:  2002-07       Impact factor: 3.295

2.  FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B.

Authors:  Alexander Grundmann; Tatyana Kuznetsova; Shamil Sh Afiyatullov; Shu-Ming Li
Journal:  Chembiochem       Date:  2008-09-01       Impact factor: 3.164

3.  Systemic efficacy of nodulisporic acid against fleas on dogs.

Authors:  W L Shoop; L M Gregory; M Zakson-Aiken; B F Michael; H W Haines; J G Ondeyka; P T Meinke; D M Schmatz
Journal:  J Parasitol       Date:  2001-04       Impact factor: 1.276

4.  Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.

Authors:  Inge A Unsöld; Shu-Ming Li
Journal:  Microbiology       Date:  2005-05       Impact factor: 2.777

5.  A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

Authors:  Junko Nakazawa; Junichiro Yajima; Takeo Usui; Masashi Ueki; Akira Takatsuki; Masaya Imoto; Yoko Y Toyoshima; Hiroyuki Osada
Journal:  Chem Biol       Date:  2003-02

6.  Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships.

Authors:  Sheo B Singh; John G Ondeyka; Hiranthi Jayasuriya; Deborah L Zink; Sookhee N Ha; Arlene Dahl-Roshak; Joyce Greene; Jennifer A Kim; McHardy M Smith; Wesley Shoop; Jan S Tkacz
Journal:  J Nat Prod       Date:  2004-09       Impact factor: 4.050

7.  The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria.

Authors:  Ute Metzger; Christoph Schall; Georg Zocher; Inge Unsöld; Edyta Stec; Shu-Ming Li; Lutz Heide; Thilo Stehle
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-12       Impact factor: 11.205

8.  A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559.

Authors:  Masahiro Ogata; Jun-ya Ueda; Midori Hoshi; Junko Hashimoto; Takuji Nakashima; Kozue Anzai; Motoki Takagi; Kazuo Shin-ya
Journal:  J Antibiot (Tokyo)       Date:  2007-10       Impact factor: 2.649

9.  CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation.

Authors:  Wen-Bing Yin; Han-Li Ruan; Lucia Westrich; Alexander Grundmann; Shu-Ming Li
Journal:  Chembiochem       Date:  2007-07-09       Impact factor: 3.164

Review 10.  The ABBA family of aromatic prenyltransferases: broadening natural product diversity.

Authors:  M Tello; T Kuzuyama; L Heide; J P Noel; S B Richard
Journal:  Cell Mol Life Sci       Date:  2008-05       Impact factor: 9.261
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