Literature DB >> 25180619

Biosynthesis of fungal indole alkaloids.

Wei Xu1, Diego J Gavia, Yi Tang.   

Abstract

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

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Year:  2014        PMID： 25180619      PMCID： PMC4162825          DOI： 10.1039/c4np00073k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  81 in total

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Review 8.  Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs.

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