Literature DB >> 17962745

Synthesis of novel N-sulfonyl monocyclic beta-lactams as potential antibacterial agents.

Aliasghar Jarrahpour1, Maaroof Zarei.   

Abstract

New cis monocyclic beta-lactams were synthesized by [2+2] Staudinger cycloaddition reactions of the imine (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)-amine and ketenes derived from different acyl chlorides and Et3N. These monocyclic beta-lactams were then cleaved by ceric ammonium nitrate (CAN) to give NH-monocyclic beta-lactams, which in turn were converted to N-sulfonyl monocyclic beta-lactams by treatment with four different sulfonyl chlorides in the presence of Et3N and 4,4-dimethyl-aminopyridine (DMAP).

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Year:  2006        PMID： 17962745      PMCID： PMC6148652          DOI： 10.3390/11010049

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  18 in total

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2.  Synthesis of novel N-(4-ethoxyphenyl) azetidin-2-ones and their oxidative N-deprotection by ceric ammonium nitrate.

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  5 in total

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