| Literature DB >> 15081019 |
Guillermo Gerona-Navarro1, M Jesús Pérez de Vega, M Teresa García-López, Graciela Andrei, Robert Snoeck, Jan Balzarini, Erik De Clercq, Rosario González-Muñiz.
Abstract
Different Phe-derived 1-acyl-beta-lactams, analogous to a series of 2-azetidinones acting as HCMV serine protease inhibitors, were synthesized. Some of these compounds were modest inhibitors of the HCMV replication. Interestingly, removal of the carbonyl group of the beta-lactam ring, most likely acting as the serine trap, resulted in an azetidine derivative with anti-HCMV activity comparable to that of the reference compound ganciclovir.Entities:
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Year: 2004 PMID： 15081019 DOI： 10.1016/j.bmcl.2004.02.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823