Literature DB >> 32071683

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

Eric M Gordon1, Matthew A J Duncton1, Brian J Wang2, Longwu Qi3, Dazhong Fan3, Xianfeng Li3, Zhi-Jie Ni3, Pingyu Ding2, Ruslan Grygorash2, Eddy Low2, Guijun Yu2, Jiawei Sun2.   

Abstract

Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.
Copyright © 2020 American Chemical Society.

Entities:  

Year:  2020        PMID： 32071683      PMCID： PMC7025374          DOI： 10.1021/acsmedchemlett.9b00534

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  14 in total

1.  N-activated β-lactams as versatile reagents for acyl carrier protein labeling.

Authors:  Gitanjeli Prasad; Jon W Amoroso; Lawrence S Borketey; Nathan A Schnarr
Journal:  Org Biomol Chem       Date:  2012-01-31       Impact factor: 3.876

Review 2.  Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.

Authors:  Helen W Boucher; George H Talbot; John S Bradley; John E Edwards; David Gilbert; Louis B Rice; Michael Scheld; Brad Spellberg; John Bartlett
Journal:  Clin Infect Dis       Date:  2009-01-01       Impact factor: 9.079

3.  The antibiotic resistance crisis: part 1: causes and threats.

Authors:  C Lee Ventola
Journal:  P T       Date:  2015-04

Review 4.  The emerging role of human esterases.

Authors:  Tatsuki Fukami; Tsuyoshi Yokoi
Journal:  Drug Metab Pharmacokinet       Date:  2012-07-17       Impact factor: 3.614

5.  Oral bioavailability of the monobactam aztreonam (SQ 26,776) in healthy subjects.

Authors:  E A Swabb; A A Sugerman; M Stern
Journal:  Antimicrob Agents Chemother       Date:  1983-04       Impact factor: 5.191

6.  Monocyclic beta-lactam antibiotics produced by bacteria.

Authors:  R B Sykes; C M Cimarusti; D P Bonner; K Bush; D M Floyd; N H Georgopapadakou; W M Koster; W C Liu; W L Parker; P A Principe; M L Rathnum; W A Slusarchyk; W H Trejo; J S Wells
Journal:  Nature       Date:  1981-06-11       Impact factor: 49.962

Review 7.  Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  R N Brogden; R C Heel
Journal:  Drugs       Date:  1986-02       Impact factor: 9.546

8.  Synthesis of novel N-sulfonyl monocyclic beta-lactams as potential antibacterial agents.

Authors:  Aliasghar Jarrahpour; Maaroof Zarei
Journal:  Molecules       Date:  2006-01-31       Impact factor: 4.411

9.  Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin.

Authors:  A Imada; K Kitano; K Kintaka; M Muroi; M Asai
Journal:  Nature       Date:  1981-02-12       Impact factor: 49.962

10.  Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

Authors:  María Jesús Martín; Raquel Rodríguez-Acebes; Yésica García-Ramos; Valentín Martínez; Carmen Murcia; Isabel Digón; Isabel Marco; Marta Pelay-Gimeno; Rogelio Fernández; Fernando Reyes; Andrés M Francesch; Simon Munt; Judit Tulla-Puche; Fernando Albericio; Carmen Cuevas
Journal:  J Am Chem Soc       Date:  2014-04-29       Impact factor: 15.419
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.