| Literature DB >> 15081015 |
James C Sutton1, Scott A Bolton, Malcolm E Davis, Karen S Hartl, Bruce Jacobson, Arvind Mathur, Martin L Ogletree, William A Slusarchyk, Robert Zahler, Steven M Seiler, Gregory S Bisacchi.
Abstract
A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase inhibitors was prepared by solid-phase methodology to quickly assess the SAR associated with distal functionality on the N1-activating group. From these studies, potent inhibitors with improved specificity were discovered.Entities:
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Year: 2004 PMID： 15081015 DOI： 10.1016/j.bmcl.2004.02.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823