Literature DB >> 17952093

Structural insight into OprD substrate specificity.

Shyamasri Biswas1, Mohammad M Mohammad, Dimki R Patel, Liviu Movileanu, Bert van den Berg.   

Abstract

OprD proteins form a large family of substrate-specific outer-membrane channels in Gram-negative bacteria. We report here the X-ray crystal structure of OprD from Pseudomonas aeruginosa, which reveals a monomeric 18-stranded beta-barrel characterized by a very narrow pore constriction, with a positively charged basic ladder on one side and an electronegative pocket on the other side. The location of highly conserved residues in OprD suggests that the structure represents the general architecture of OprD channels.

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Year:  2007        PMID： 17952093     DOI： 10.1038/nsmb1304

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  35 in total

1.  Redesign of a plugged beta-barrel membrane protein.

Authors:  Mohammad M Mohammad; Khalil R Howard; Liviu Movileanu
Journal:  J Biol Chem       Date:  2010-12-28       Impact factor: 5.157

Review 2.  Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes.

Authors:  Jamie Parkin; Matthieu Chavent; Syma Khalid
Journal:  Biophys J       Date:  2015-08-04       Impact factor: 4.033

3.  Probing the binding affinities of imipenem and ertapenem for outer membrane carboxylate channel D1 (OccD1) from P. aeruginosa: simulation studies.

Authors:  Kamolrat Somboon; Jitti Niramitranon; Prapasiri Pongprayoon
Journal:  J Mol Model       Date:  2017-07-17       Impact factor: 1.810

4.  OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity.

Authors:  Jiaming Liu; Elif Eren; Jagamya Vijayaraghavan; Belete R Cheneke; Mridhu Indic; Bert van den Berg; Liviu Movileanu
Journal:  Biochemistry       Date:  2012-03-08       Impact factor: 3.162

5.  Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa.

Authors:  Elif Eren; Jamie Parkin; Ayodele Adelanwa; Belete Cheneke; Liviu Movileanu; Syma Khalid; Bert van den Berg
Journal:  J Biol Chem       Date:  2013-03-06       Impact factor: 5.157

6.  Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Authors:  Jun Yong Choi; Mark S Plummer; Jeremy Starr; Charlene R Desbonnet; Holly Soutter; Jeanne Chang; J Richard Miller; Keith Dillman; Alita A Miller; William R Roush
Journal:  J Med Chem       Date:  2012-01-13       Impact factor: 7.446

7.  Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa.

Authors:  Jiaming Liu; Aaron J Wolfe; Elif Eren; Jagamya Vijayaraghavan; Mridhu Indic; Bert van den Berg; Liviu Movileanu
Journal:  Biochim Biophys Acta       Date:  2012-07-21

8.  Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients.

Authors:  Leonie Greipel; Sebastian Fischer; Jens Klockgether; Marie Dorda; Samira Mielke; Lutz Wiehlmann; Nina Cramer; Burkhard Tümmler
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

9.  Does the lipid environment impact the open-state conductance of an engineered β-barrel protein nanopore?

Authors:  Noriko Tomita; Mohammad M Mohammad; David J Niedzwiecki; Makoto Ohta; Liviu Movileanu
Journal:  Biochim Biophys Acta       Date:  2012-12-11

Review 10.  Structure, function, and evolution of bacterial ATP-binding cassette systems.

Authors:  Amy L Davidson; Elie Dassa; Cedric Orelle; Jue Chen
Journal:  Microbiol Mol Biol Rev       Date:  2008-06       Impact factor: 11.056
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