| Literature DB >> 17923406 |
Shubhasish Mukherjee1, Carolyn A Robinson, Andrew G Howe, Tali Mazor, Peter A Wood, Sameer Urgaonkar, Alan M Hebert, Debabrata Raychaudhuri, Jared T Shaw.
Abstract
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20+/-5% at 100microM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.Entities:
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Year: 2007 PMID： 17923406 PMCID： PMC3335298 DOI： 10.1016/j.bmcl.2007.09.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823