Literature DB >> 12096015

2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

E Lucile White1, William J Suling, Larry J Ross, Lainne E Seitz, Robert C Reynolds.   

Abstract

Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of tubulin, FtsZ. Initial screening of 200 2-alkoxycarbonylpyridines found several that inhibited M. tuberculosis growth. Two compounds, SRI-3072 and SRI-7614, inhibited FtsZ polymerization and were equipotent against susceptible and single-drug-resistant strains of M. tuberculosis. In addition, SRI-3072 reduced the growth of M. tuberculosis in mouse bone marrow macrophages. Our results suggest that these types of compound might be developed into antitubercular drugs effective against the current multidrug-resistant strains of M. tuberculosis.

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Year:  2002        PMID： 12096015     DOI： 10.1093/jac/dkf075

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  33 in total

1.  Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.

Authors:  Danielle N Margalit; Laura Romberg; Rebecca B Mets; Alan M Hebert; Timothy J Mitchison; Marc W Kirschner; Debabrata RayChaudhuri
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-02       Impact factor: 11.205

Review 2.  Drug discovery targeting cell division proteins, microtubules and FtsZ.

Authors:  Iwao Ojima; Kunal Kumar; Divya Awasthi; Jacob G Vineberg
Journal:  Bioorg Med Chem       Date:  2014-03-05       Impact factor: 3.641

3.  Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Authors:  Sameer Urgaonkar; Henry S La Pierre; Israel Meir; Henrik Lund; Debabrata RayChaudhuri; Jared T Shaw
Journal:  Org Lett       Date:  2005-12-08       Impact factor: 6.005

4.  6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Authors:  Ashish K Pathak; Vibha Pathak; Lainne E Seitz; William J Suling; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

5.  Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Authors:  Kunal Kumar; Divya Awasthi; Seung-Yub Lee; Ilaria Zanardi; Bela Ruzsicska; Susan Knudson; Peter J Tonge; Richard A Slayden; Iwao Ojima
Journal:  J Med Chem       Date:  2010-12-02       Impact factor: 7.446

6.  Nitrotriazole- and imidazole-based amides and sulfonamides as antitubercular agents.

Authors:  Maria V Papadopoulou; William D Bloomer; Howard S Rosenzweig; Alexander Arena; Francisco Arrieta; Joseph C J Rebolledo; Diane K Smith
Journal:  Antimicrob Agents Chemother       Date:  2014-09-02       Impact factor: 5.191

7.  Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.

Authors:  Esther Vicente; Raquel Villar; Asunción Burguete; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Joseph A Maddry; Anne J Lenaerts; Scott G Franzblau; Sang-Hyun Cho; Antonio Monge; Robert C Goldman
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

8.  N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.

Authors:  Shubhasish Mukherjee; Carolyn A Robinson; Andrew G Howe; Tali Mazor; Peter A Wood; Sameer Urgaonkar; Alan M Hebert; Debabrata Raychaudhuri; Jared T Shaw
Journal:  Bioorg Med Chem Lett       Date:  2007-09-07       Impact factor: 2.823

Review 9.  Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

Authors:  Krupanandan Haranahalli; Simon Tong; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2016-05-05       Impact factor: 3.641

10.  Mycobacterium tuberculosis cells growing in macrophages are filamentous and deficient in FtsZ rings.

Authors:  Ashwini Chauhan; Murty V V S Madiraju; Marek Fol; Hava Lofton; Erin Maloney; Robert Reynolds; Malini Rajagopalan
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490
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