Literature DB >> 15149666

A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.

R C Reynolds1, S Srivastava, L J Ross, W J Suling, E L White.   

Abstract

The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented.

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Year:  2004        PMID： 15149666     DOI： 10.1016/j.bmcl.2004.04.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

Review 1.  Drug discovery targeting cell division proteins, microtubules and FtsZ.

Authors:  Iwao Ojima; Kunal Kumar; Divya Awasthi; Jacob G Vineberg
Journal:  Bioorg Med Chem       Date:  2014-03-05       Impact factor: 3.641

2.  Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Authors:  Sameer Urgaonkar; Henry S La Pierre; Israel Meir; Henrik Lund; Debabrata RayChaudhuri; Jared T Shaw
Journal:  Org Lett       Date:  2005-12-08       Impact factor: 6.005

3.  Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

Authors:  Malvika Kaul; Yongzheng Zhang; Ajit K Parhi; Edmond J Lavoie; Steve Tuske; Eddy Arnold; John E Kerrigan; Daniel S Pilch
Journal:  Biochimie       Date:  2013-06-25       Impact factor: 4.079

4.  A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.

Authors:  Malvika Kaul; Ajit K Parhi; Yongzheng Zhang; Edmond J LaVoie; Steve Tuske; Eddy Arnold; John E Kerrigan; Daniel S Pilch
Journal:  J Med Chem       Date:  2012-10-26       Impact factor: 7.446

5.  Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Authors:  Kunal Kumar; Divya Awasthi; Seung-Yub Lee; Ilaria Zanardi; Bela Ruzsicska; Susan Knudson; Peter J Tonge; Richard A Slayden; Iwao Ojima
Journal:  J Med Chem       Date:  2010-12-02       Impact factor: 7.446

6.  Benzimidazole-based antibacterial agents against Francisella tularensis.

Authors:  Kunal Kumar; Divya Awasthi; Seung-Yub Lee; Jason E Cummings; Susan E Knudson; Richard A Slayden; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2013-04-03       Impact factor: 3.641

7.  Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.

Authors:  Iwao Ojima; Divya Awasthi; Longfei Wei; Krupanandan Haranahalli
Journal:  J Fluor Chem       Date:  2016-07-29       Impact factor: 2.050

8.  N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli.

Authors:  Shubhasish Mukherjee; Carolyn A Robinson; Andrew G Howe; Tali Mazor; Peter A Wood; Sameer Urgaonkar; Alan M Hebert; Debabrata Raychaudhuri; Jared T Shaw
Journal:  Bioorg Med Chem Lett       Date:  2007-09-07       Impact factor: 2.823

Review 9.  Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

Authors:  Krupanandan Haranahalli; Simon Tong; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2016-05-05       Impact factor: 3.641

10.  Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

Authors:  Bora Park; Divya Awasthi; Soumya R Chowdhury; Eduard H Melief; Kunal Kumar; Susan E Knudson; Richard A Slayden; Iwao Ojima
Journal:  Bioorg Med Chem       Date:  2014-04-01       Impact factor: 3.641
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