Literature DB >> 17923172

Synthesis and anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives.

Maria Cristina da Silva Lourenço1, Marcelle de Lima Ferreira, Marcus Vinícius Nora de Souza, Mônica Amado Peralta, Thatyana Rocha Alves Vasconcelos, Maria das Graças M O Henriques.   

Abstract

A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 microg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.

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Year:  2007        PMID： 17923172     DOI： 10.1016/j.ejmech.2007.08.003

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  19 in total

1.  N'-(4-Bromo-phenyl-sulfon-yl)isonicotino-hydrazide.

Authors:  Islam Ullah Khan; Muhammad Ashfaq; Muhammad Nadeem Arshad; Hamad Ahmad; Ghulam Mustafa
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-25

2.  Benzyl N-((S)-2-hydr-oxy-1-{N'-[(E)-2-methoxy-benzyl-idene]hydrazinecarbon-yl}eth-yl)carbamate from synchrotron data.

Authors:  Alessandra C Pinheiro; Marcus V N de Souza; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-31

3.  (E)-N'-(3-Benz-yloxy-4-methoxy-benzyl-idene)isonicotinohydrazide.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Wan-Sin Loh; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-09-26

4.  (E)-N'-(2,4,6-Trihydroxy-benzyl-idene)isonicotinohydrazide sesquihydrate.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Wan-Sin Loh; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-28

5.  (E)-N'-(2,3,4-Trimethoxy-benzyl-idene)isonicotinohydrazide.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Chin Sing Yeap; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-30

6.  (E)-N'-(2,4,5-Trimethoxy-benzyl-idene)isonicotinohydrazide dihydrate.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Chin Sing Yeap; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-30

7.  (E)-N'-[(E)-3-(4-Hydr-oxy-3-methoxy-phen-yl)allyl-idene]isonicotinohydrazide.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Ching Kheng Quah; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-09

8.  (E)-N'-(2-Benzyl-oxybenzyl-idene)isonicotinohydrazide methanol solvate monohydrate.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Madhukar Hemamalini; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-15

9.  (E)-N'-(2,4,6-Trimethyl-benzyl-idene)isonicotinohydrazide.

Authors:  H S Naveenkumar; Amirin Sadikun; Pazilah Ibrahim; Jia Hao Goh; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

10.  Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid.

Authors:  Michael J Hearn; Michael H Cynamon; Michaeline F Chen; Rebecca Coppins; Jessica Davis; Helen Joo-On Kang; Abigail Noble; Becky Tu-Sekine; Marianne S Terrot; Daniella Trombino; Minh Thai; Eleanor R Webster; Rebecca Wilson
Journal:  Eur J Med Chem       Date:  2009-05-21       Impact factor: 6.514
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