Literature DB >> 17898708

Advances in the treatment of tuberculosis.

Y Zhang1.   

Abstract

The current 6-month tuberculosis (TB) therapy is suboptimal with significant side effects and a poor patient compliance problem that frequently selects drug-resistant organisms. The increasing drug-resistant TB problem highlights the need to develop new and more effective drugs. Significant progress has been made recently with several new drug candidates currently in clinical trials. Improved understanding of persister biology and development of persister drugs are likely to be important for developing a more effective therapy.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17898708     DOI: 10.1038/sj.clpt.6100362

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  20 in total

1.  The frequency of persisters in Escherichia coli reflects the kinetics of awakening from dormancy.

Authors:  Arvi Jõers; Niilo Kaldalu; Tanel Tenson
Journal:  J Bacteriol       Date:  2010-04-30       Impact factor: 3.490

Review 2.  New antituberculous drugs in development.

Authors:  Umesh G Lalloo; Anish Ambaram
Journal:  Curr HIV/AIDS Rep       Date:  2010-08       Impact factor: 5.071

3.  Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.

Authors:  Ying Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-15       Impact factor: 11.205

4.  A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis.

Authors:  Xun Liu; Jinxiu Peng; Lina Hu; Yanping Luo; Hongxia Niu; Chunxiang Bai; Qian Wang; Fei Li; Hongjuan Yu; Bingxiang Wang; Huiyu Chen; Ming Guo; Bingdong Zhu
Journal:  Hum Vaccin Immunother       Date:  2016-02-22       Impact factor: 3.452

5.  Age of inoculum strongly influences persister frequency and can mask effects of mutations implicated in altered persistence.

Authors:  Hannes Luidalepp; Arvi Jõers; Niilo Kaldalu; Tanel Tenson
Journal:  J Bacteriol       Date:  2011-05-20       Impact factor: 3.490

6.  Inhalation of recombinant adenovirus expressing granulysin protects mice infected with Mycobacterium tuberculosis.

Authors:  J Ma; J Lu; H Huang; X Teng; M Tian; Q Yu; X Yuan; Y Jing; C Shi; J Li; X Fan
Journal:  Gene Ther       Date:  2015-07-16       Impact factor: 5.250

7.  In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78.

Authors:  Urs Duthaler; Thomas A Smith; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2010-08-23       Impact factor: 5.191

8.  Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PAO1.

Authors:  Jerrylynn Manuel; George G Zhanel; Teresa de Kievit
Journal:  Antimicrob Agents Chemother       Date:  2010-09-20       Impact factor: 5.191

9.  Interpreting phenotypic antibiotic tolerance and persister cells as evolution via epigenetic inheritance.

Authors:  Troy Day
Journal:  Mol Ecol       Date:  2016-04-20       Impact factor: 6.185

10.  Fluoroquinolone resistance in Mycobacterium tuberculosis and mutations in gyrA and gyrB.

Authors:  Andrea Von Groll; Anandi Martin; Pontus Jureen; Sven Hoffner; Peter Vandamme; Françoise Portaels; Juan Carlos Palomino; Pedro Almeida da Silva
Journal:  Antimicrob Agents Chemother       Date:  2009-08-17       Impact factor: 5.191

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.