Literature DB >> 17886323

A small-molecule antagonist of the hedgehog signaling pathway.

Jongkook Lee1, Xu Wu, Marina Pasca di Magliano, Eric C Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y Cho, Peter G Schultz.   

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Year:  2007        PMID: 17886323     DOI: 10.1002/cbic.200700403

Source DB:  PubMed          Journal:  Chembiochem        ISSN: 1439-4227            Impact factor:   3.164


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  12 in total

Review 1.  Embryonic stem cell application in drug discovery.

Authors:  Yi-jia Lou; Xing-guang Liang
Journal:  Acta Pharmacol Sin       Date:  2011-01-10       Impact factor: 6.150

2.  Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum.

Authors:  Midori A Arai; Ryuta Akamine; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  J Nat Med       Date:  2015-05-31       Impact factor: 2.343

3.  GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.

Authors:  Junsheng Fu; Mariana Rodova; Sanjit K Roy; Jay Sharma; Karan P Singh; Rakesh K Srivastava; Sharmila Shankar
Journal:  Cancer Lett       Date:  2012-11-28       Impact factor: 8.679

Review 4.  Synthesis at the interface of chemistry and biology.

Authors:  Xu Wu; Peter G Schultz
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

5.  Converse conformational control of smoothened activity by structurally related small molecules.

Authors:  Hongbo Yang; Jing Xiang; Nengdong Wang; Yun Zhao; Joel Hyman; Song Li; Jin Jiang; James K Chen; Zhen Yang; Shuo Lin
Journal:  J Biol Chem       Date:  2009-04-14       Impact factor: 5.157

6.  Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Authors:  Helen O Oladapo; Michael Tarpley; Scott J Sauer; Kezia A Addo; Shalonda M Ingram; Dillon Strepay; Ben K Ehe; Lhoucine Chdid; Michael Trinkler; Jose R Roques; David B Darr; Jodie M Fleming; Gayathri R Devi; Kevin P Williams
Journal:  Cancer Lett       Date:  2017-09-28       Impact factor: 8.679

Review 7.  Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

Authors:  Neeraj Mahindroo; Chandanamali Punchihewa; Naoaki Fujii
Journal:  J Med Chem       Date:  2009-07-09       Impact factor: 7.446

8.  Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.

Authors:  Brahma N Singh; Junsheng Fu; Rakesh K Srivastava; Sharmila Shankar
Journal:  PLoS One       Date:  2011-11-08       Impact factor: 3.240

Review 9.  Hedgehog signaling in cancer stem cells: a focus on hematological cancers.

Authors:  Victoria Campbell; Mhairi Copland
Journal:  Stem Cells Cloning       Date:  2015-01-16

10.  Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation.

Authors:  Midori A Arai; Kyoko Uchida; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  Beilstein J Org Chem       Date:  2014-01-13       Impact factor: 2.883

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