Literature DB >> 26026497

Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum.

Midori A Arai1, Ryuta Akamine, Samir K Sadhu, Firoj Ahmed, Masami Ishibashi.   

Abstract

The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

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Year:  2015        PMID： 26026497     DOI： 10.1007/s11418-015-0922-8

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  23 in total

1.  Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Authors:  Juliet A Williams; Oivin M Guicherit; Beatrice I Zaharian; Yin Xu; Ling Chai; Hynek Wichterle; Charlene Kon; Christine Gatchalian; Jeffery A Porter; Lee L Rubin; Frank Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-04       Impact factor: 11.205

2.  A small-molecule antagonist of the hedgehog signaling pathway.

Authors:  Jongkook Lee; Xu Wu; Marina Pasca di Magliano; Eric C Peters; Yan Wang; Jiyong Hong; Metthias Hebrok; Sheng Ding; Charles Y Cho; Peter G Schultz
Journal:  Chembiochem       Date:  2007-11-05       Impact factor: 3.164

Review 3.  Roles for Hedgehog signaling in adult organ homeostasis and repair.

Authors:  Ralitsa Petrova; Alexandra L Joyner
Journal:  Development       Date:  2014-09       Impact factor: 6.868

Review 4.  Targeting the Hedgehog signaling pathway for cancer therapy.

Authors:  Yiwei Li; Ma'in Y Maitah; Aamir Ahmad; Dejuan Kong; Bin Bao; Fazlul H Sarkar
Journal:  Expert Opin Ther Targets       Date:  2012-01       Impact factor: 6.902

5.  New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.

Authors:  Yusnita Rifai; Midori A Arai; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  Bioorg Med Chem Lett       Date:  2010-12-05       Impact factor: 2.823

6.  Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

Authors:  Matthias Lauth; Asa Bergström; Takashi Shimokawa; Rune Toftgård
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-09       Impact factor: 11.205

7.  Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex.

Authors:  Midori A Arai; Teruhisa Fujimatsu; Kyoko Uchida; Samir K Sadhu; Firoj Ahmed; Masami Ishibashi
Journal:  Mol Biosyst       Date:  2013-05

8.  Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

Authors:  Midori A Arai; Chikashi Tateno; Takahiro Hosoya; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  Bioorg Med Chem       Date:  2008-09-24       Impact factor: 3.641

9.  Total syntheses of (+/-)-crinine, (+/-)-crinamine, and (+/-)-6a-epi-crinamine via the regioselective synthesis and Diels-Alder reaction of 3-aryl-5-bromo-2-pyrone.

Authors:  Thanh Tam Nguyen; Jayhyok Chang; Eun-Ju Jung; Cheon-Gyu Cho
Journal:  J Org Chem       Date:  2008-07-16       Impact factor: 4.354

10.  Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Authors:  Elissaveta Petrova; Jessica Rios-Esteves; Ouathek Ouerfelli; J Fraser Glickman; Marilyn D Resh
Journal:  Nat Chem Biol       Date:  2013-02-17       Impact factor: 15.040
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  5 in total

1.  Robust optimization for the simultaneous enhancement of nitric oxide inhibition and reduction of hepatotoxicity from green tea catechins.

Authors:  Min Chae Kim; Tuan-Ho Le; Cheng Bao; Jin Tae Kim; Hyang Sook Chun; Sangmun Shin; Hong Jin Lee
Journal:  Food Sci Biotechnol       Date:  2017-07-14       Impact factor: 2.391

2.  Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.

Authors:  Cinzia Ingallina; Pedro M Costa; Francesca Ghirga; Rebecca Klippstein; Julie T Wang; Simone Berardozzi; Naomi Hodgins; Paola Infante; Steven M Pollard; Bruno Botta; Khuloud T Al-Jamal
Journal:  Nanomedicine (Lond)       Date:  2017-03-21       Impact factor: 5.307

Review 3.  Screening for natural products that affect Wnt signaling activity.

Authors:  Masami Ishibashi
Journal:  J Nat Med       Date:  2019-05-30       Impact factor: 2.343

4.  Activation of Sonic Hedgehog Signaling Is Associated with Human Osteosarcoma Cells Radioresistance Characterized by Increased Proliferation, Migration, and Invasion.

Authors:  Wei Qu; Dichen Li; Yufei Wang; Qining Wu; Dingjun Hao
Journal:  Med Sci Monit       Date:  2018-06-04

5.  Antiproliferative Effects of Alkaloids from the Bulbs of Crinum abyscinicum Hochst. ExA. Rich.

Authors:  Besufekad Abebe; Solomon Tadesse; Ariaya Hymete; Daniel Bisrat
Journal:  Evid Based Complement Alternat Med       Date:  2020-10-31       Impact factor: 2.629
  5 in total

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