Literature DB >> 19309080

Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

Neeraj Mahindroo1, Chandanamali Punchihewa, Naoaki Fujii.   

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Year:  2009        PMID： 19309080      PMCID： PMC2743241          DOI： 10.1021/jm801420y

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  124 in total

Review 1.  Hedgehog signaling in animal development: paradigms and principles.

Authors:  P W Ingham; A P McMahon
Journal:  Genes Dev       Date:  2001-12-01       Impact factor: 11.361

2.  Hedgehog acts as a somatic stem cell factor in the Drosophila ovary.

Authors:  Y Zhang; D Kalderon
Journal:  Nature       Date:  2001-03-29       Impact factor: 49.962

3.  Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

Authors:  J P Incardona; W Gaffield; Y Lange; A Cooney; P G Pentchev; S Liu; J A Watson; R P Kapur; H Roelink
Journal:  Dev Biol       Date:  2000-08-15       Impact factor: 3.582

4.  Regulation of gli activity by all-trans retinoic acid in mouse keratinocytes.

Authors:  P Goyette; D Allan; P Peschard; C F Chen; W Wang; D Lohnes
Journal:  Cancer Res       Date:  2000-10-01       Impact factor: 12.701

5.  The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.

Authors:  N Dahmane; P Sánchez; Y Gitton; V Palma; T Sun; M Beyna; H Weiner; A Ruiz i Altaba
Journal:  Development       Date:  2001-12       Impact factor: 6.868

6.  Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation.

Authors:  S Spinella-Jaegle; G Rawadi; S Kawai; S Gallea; C Faucheu; P Mollat; B Courtois; B Bergaud; V Ramez; A M Blanchet; G Adelmant; R Baron; S Roman-Roman
Journal:  J Cell Sci       Date:  2001-06       Impact factor: 5.285

7.  Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Authors:  J Taipale; J K Chen; M K Cooper; B Wang; R K Mann; L Milenkovic; M P Scott; P A Beachy
Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

8.  Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

Authors:  M Nilsson; A B Undèn; D Krause; U Malmqwist; K Raza; P G Zaphiropoulos; R Toftgård
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

9.  Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.

Authors:  H L Park; C Bai; K A Platt; M P Matise; A Beeghly; C C Hui; M Nakashima; A L Joyner
Journal:  Development       Date:  2000-04       Impact factor: 6.868

10.  A small molecule that binds Hedgehog and blocks its signaling in human cells.

Authors:  Benjamin Z Stanton; Lee F Peng; Nicole Maloof; Kazuo Nakai; Xiang Wang; Jay L Duffner; Kennedy M Taveras; Joel M Hyman; Sam W Lee; Angela N Koehler; James K Chen; Julia L Fox; Anna Mandinova; Stuart L Schreiber
Journal:  Nat Chem Biol       Date:  2009-01-18       Impact factor: 15.040
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  30 in total

Review 1.  Targeting Hedgehog--a cancer stem cell pathway.

Authors:  Akil A Merchant; William Matsui
Journal:  Clin Cancer Res       Date:  2010-06-08       Impact factor: 12.531

2.  A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.

Authors:  Keisuke Kakisaka; Sophie C Cazanave; Nathan W Werneburg; Nataliya Razumilava; Joachim C Mertens; Steve F Bronk; Gregory J Gores
Journal:  J Hepatol       Date:  2012-05-26       Impact factor: 25.083

Review 3.  Forkhead box M1 transcription factor: a novel target for cancer therapy.

Authors:  Zhiwei Wang; Aamir Ahmad; Yiwei Li; Sanjeev Banerjee; Dejuan Kong; Fazlul H Sarkar
Journal:  Cancer Treat Rev       Date:  2009-12-22       Impact factor: 12.111

Review 4.  Molecular basis of basal cell carcinoma.

Authors:  Erik Montagna; Otávio Sérgio Lopes
Journal:  An Bras Dermatol       Date:  2017 Jul-Aug       Impact factor: 1.896

5.  Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.

Authors:  Shifeng Pan; Xu Wu; Jiqing Jiang; Wenqi Gao; Yongqin Wan; Dai Cheng; Dong Han; Jun Liu; Nathan P Englund; Yan Wang; Stefan Peukert; Karen Miller-Moslin; Jing Yuan; Ribo Guo; Melissa Matsumoto; Anthony Vattay; Yun Jiang; Jeffrey Tsao; Fangxian Sun; AnneMarie C Pferdekamper; Stephanie Dodd; Tove Tuntland; Wieslawa Maniara; Joseph F Kelleher; Yung-Mae Yao; Markus Warmuth; Juliet Williams; Marion Dorsch
Journal:  ACS Med Chem Lett       Date:  2010-03-16       Impact factor: 4.345

6.  Progress toward a Convergent, Asymmetric Synthesis of Jervine.

Authors:  Blane P Zavesky; Pedro De Jesús Cruz; Jeffrey S Johnson
Journal:  Org Lett       Date:  2020-04-14       Impact factor: 6.005

7.  Hedgehog/Gli1 signal pathway facilitates proliferation, invasion, and migration of cutaneous SCC through regulating VEGF.

Authors:  Qian Sun; Jing Bai; Renrong Lv
Journal:  Tumour Biol       Date:  2016-10-17

8.  Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

Authors:  Jiangbo Wang; Robert A Mook; Jiuyi Lu; David M Gooden; Anthony Ribeiro; Anchen Guo; Larry S Barak; H Kim Lyerly; Wei Chen
Journal:  Bioorg Med Chem       Date:  2012-09-23       Impact factor: 3.641

9.  Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.

Authors:  Jonathan E Hempel; Adrian G Cadar; Charles C Hong
Journal:  Bioorg Med Chem Lett       Date:  2016-03-07       Impact factor: 2.823

10.  A phase I and pharmacokinetic study of taladegib, a Smoothened inhibitor, in Japanese patients with advanced solid tumors.

Authors:  Hideki Ueno; Shunsuke Kondo; Shusuke Yoshikawa; Koichi Inoue; Valérie Andre; Masaomi Tajimi; Haruyasu Murakami
Journal:  Invest New Drugs       Date:  2018-02-17       Impact factor: 3.850
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