| Literature DB >> 17882539 |
Jamie M Kleinman1, Diana L Robins, Pamela E Ventola, Juhi Pandey, Hilary C Boorstein, Emma L Esser, Leandra B Wilson, Michael A Rosenthal, Saasha Sutera, Alyssa D Verbalis, Marianne Barton, Sarah Hodgson, James Green, Thyde Dumont-Mathieu, Fred Volkmar, Katarzyna Chawarska, Ami Klin, Deborah Fein.
Abstract
Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16-30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Rescreening was performed on 1,416 children aged 42-54 months. Time 1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the followup telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD.Entities:
Mesh：
Year: 2008 PMID： 17882539 PMCID： PMC3612529 DOI： 10.1007/s10803-007-0450-9
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257