Literature DB >> 1779706

Sterol biosynthesis inhibitors: their current status and modes of action.

E I Mercer1.   

Abstract

The mechanism of each of the reactions in the post-squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.

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Year:  1991        PMID： 1779706     DOI： 10.1007/bf02536422

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  60 in total

1.  Stoichiometry of 4-methyl sterol oxidase of rat liver microsomes.

Authors:  J L Gaylor; Y Miyake; T Yamano
Journal:  J Biol Chem       Date:  1975-09-25       Impact factor: 5.157

Review 2.  Inhibition of sterol biosynthesis enzymes in vitro by analogues of high-energy carbocationic intermediates.

Authors:  A Rahier; M Taton; P Benveniste
Journal:  Biochem Soc Trans       Date:  1990-02       Impact factor: 5.407

3.  Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes.

Authors:  Y Aoyama; Y Yoshida; R Sato
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

4.  Control of fungal sterol C-24 transalkylation: importance to developmental regulation.

Authors:  W D Nes; P K Hanners; E J Parish
Journal:  Biochem Biophys Res Commun       Date:  1986-09-14       Impact factor: 3.575

5.  Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process.

Authors:  J M Trzaskos; R T Fischer; M F Favata
Journal:  J Biol Chem       Date:  1986-12-25       Impact factor: 5.157

6.  Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties.

Authors:  Y Yoshida; Y Aoyama
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

7.  Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent.

Authors:  P R Hays; L W Parks; H D Pierce; A C Oehlschlager
Journal:  Lipids       Date:  1977-08       Impact factor: 1.880

8.  Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives.

Authors:  A Rahier; J C Génot; F Schuber; P Benveniste; A S Narula
Journal:  J Biol Chem       Date:  1984-12-25       Impact factor: 5.157

9.  Design of high energy intermediate analogues to study sterol biosynthesis in higher plants.

Authors:  A Rahier; M Taton; P Bouvier-Navé; P Schmitt; P Benveniste; F Schuber; A S Narula; L Cattel; C Anding; P Place
Journal:  Lipids       Date:  1986-01       Impact factor: 1.880

10.  Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation.

Authors:  J M Trzaskos; W D Bowen; A Shafiee; R T Fischer; J L Gaylor
Journal:  J Biol Chem       Date:  1984-11-10       Impact factor: 5.157
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  13 in total

Review 1.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

Review 2.  Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates.

Authors:  Karine Auclair; Vanja Polic
Journal:  Adv Exp Med Biol       Date:  2015       Impact factor: 2.622

3.  Molecular cloning and expression of the human delta7-sterol reductase.

Authors:  F F Moebius; B U Fitzky; J N Lee; Y K Paik; H Glossmann
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

Review 4.  Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.

Authors:  Vanja Polic; Karine Auclair
Journal:  Bioorg Med Chem       Date:  2014-06-25       Impact factor: 3.641

5.  C27 to C32 sterols found in Pneumocystis, an opportunistic pathogen of immunocompromised mammals.

Authors:  E S Kaneshiro; M A Wyder
Journal:  Lipids       Date:  2000-03       Impact factor: 1.880

6.  Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii.

Authors:  D H Beach; F Chen; M T Cushion; R S Macomber; G A Krudy; M A Wyder; E S Kaneshiro
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

7.  The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae.

Authors:  S Silve; P Leplatois; A Josse; P H Dupuy; C Lanau; M Kaghad; C Dhers; C Picard; A Rahier; M Taton; G Le Fur; D Caput; P Ferrara; G Loison
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272

8.  Isolation of the ERG2 gene, encoding sterol delta 8-->delta 7 isomerase, from the rice blast fungus Magnaporthe grisea and its expression in the maize smut pathogen Ustilago maydis.

Authors:  J P Keon; C S James; S Court; C Baden-Daintree; A M Bailey; R S Burden; M Bard; J A Hargreaves
Journal:  Curr Genet       Date:  1994-06       Impact factor: 3.886

9.  Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae.

Authors:  W M Casey; G A Keesler; L W Parks
Journal:  J Bacteriol       Date:  1992-11       Impact factor: 3.490

10.  Antifungals: need to search for a new molecular target.

Authors:  A T Sangamwar; U D Deshpande; S S Pekamwar
Journal:  Indian J Pharm Sci       Date:  2008 Jul-Aug       Impact factor: 0.975
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