Literature DB >> 331008

Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent.

P R Hays, L W Parks, H D Pierce, A C Oehlschlager.   

Abstract

15-Aza-25-methylene-D-homocholesta-8,14-dien-3beta-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthetis in Saccharomyces cerevisiae strain 3701B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3beta-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the delta14 sterol reductase.

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Year:  1977        PMID： 331008     DOI： 10.1007/bf02533762

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

1.  New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization.

Authors:  K H Michel; R L Hamill; S H Larsen; R H Williams
Journal:  J Antibiot (Tokyo)       Date:  1975-02       Impact factor: 2.649

2.  Biosynthesis of terpenes and steroids. IX. The sterols of some mutant yeasts and their relationship to the biosynthesis of ergosterol.

Authors:  D H Barton; J E Corrie; M Bard; R A Woods
Journal:  J Chem Soc Perkin 1       Date:  1974

3.  Sterol transmethylation during aerobic adaptation of yeast.

Authors:  L W Parks; C Anding; G Ourisson
Journal:  Eur J Biochem       Date:  1974-04-16

4.  Biosynthesis of ergosterol in yeast. Evidence for multiple pathways.

Authors:  M Fryberg; A C Oehlschlager; A M Unrau
Journal:  J Am Chem Soc       Date:  1973-08-22       Impact factor: 15.419

5.  Effects of triparanol and AY-9944 upon sterol biosynthesis in Chorella.

Authors:  G W Patterson; P J Doyle; L G Dickson; J T Chan
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

6.  Structure of antibiotic A 25822 B, a novel nitrogen-containing C28-sterol with antifungal properties.

Authors:  J W Chamberlin; M O Chaney; S Chen; P V Demarco; N D Jones; J L Occolowitz
Journal:  J Antibiot (Tokyo)       Date:  1974-12       Impact factor: 2.649

7.  Enzymatic analysis of C27 sterol-accumulating yeast strains.

Authors:  R B Bailey; L Miller; L W Parks
Journal:  J Bacteriol       Date:  1976-05       Impact factor: 3.490

8.  Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.

Authors:  B N Lutsky; H M Hsiung; G J Schroepfer
Journal:  Lipids       Date:  1975-01       Impact factor: 1.880

9.  Homoazasterol-mediated inhibition of yeast sterol biosynthesis.

Authors:  R B Bailey; P R Hays; L W Parks
Journal:  J Bacteriol       Date:  1976-12       Impact factor: 3.490

10.  The induced biosynthesis of 7-dehydrocholesterols in yeast: potential sources of new provitamin D3 analogs.

Authors:  L Avruch; S Fischer; H Pierce; A C Oehlschlager
Journal:  Can J Biochem       Date:  1976-07
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  11 in total

1.  Aspects of sterol metabolism in the yeast Saccharomyces cerevisiae and in Phytophthora.

Authors:  L W Parks; C McLean-Bowen; C K Bottema; F R Taylor; R Gonzales; B W Jensen; J R Ramp
Journal:  Lipids       Date:  1982-03       Impact factor: 1.880

2.  Growth and antifungal homoazasterol production in Geotrichum flavo-brunneum.

Authors:  R J Rodriguez; L W Parks
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

3.  Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans.

Authors:  N H Georgopapadakou; B A Dix; S A Smith; J Freudenberger; P T Funke
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

4.  Production of a novel steroid sulfate metabolite [4,4,24-trimethylcholesta-8,14,24(28)-trien-2 alpha,3 beta,11 alpha,12 beta-tetrol 12-acetate, 3-sulfate] by Fusarium species and its biological activity.

Authors:  H R Burmeister; R F Vesonder
Journal:  Appl Environ Microbiol       Date:  1990-10       Impact factor: 4.792

Review 5.  Systemically administered antifungal agents. A review of their clinical pharmacology and therapeutic applications.

Authors:  C A Lyman; T J Walsh
Journal:  Drugs       Date:  1992-07       Impact factor: 9.546

6.  Sterols in yeast subcellular fractions.

Authors:  L W Parks; C McLean-Bowen; F R Taylor; S Hough
Journal:  Lipids       Date:  1978-10       Impact factor: 1.880

Review 7.  Sterol biosynthesis inhibitors: their current status and modes of action.

Authors:  E I Mercer
Journal:  Lipids       Date:  1991-08       Impact factor: 1.880

8.  Mode of action of the azasteroid antibiotic 15-aza-24 methylene-d-homocholesta-8,14-dien-3 beta-ol in Ustilago maydis.

Authors:  C P Woloshuk; H D Sisler; S R Dutky
Journal:  Antimicrob Agents Chemother       Date:  1979-07       Impact factor: 5.191

9.  Relationship between antifungal activity and inhibition of sterol biosynthesis in miconazole, clotrimazole, and 15-azasterol.

Authors:  F R Taylor; R J Rodriguez; L W Parks
Journal:  Antimicrob Agents Chemother       Date:  1983-04       Impact factor: 5.191

Review 10.  Biochemical and physiological effects of sterol alterations in yeast--a review.

Authors:  L W Parks; S J Smith; J H Crowley
Journal:  Lipids       Date:  1995-03       Impact factor: 1.880
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