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Literature DB >> 2185086

Inhibition of sterol biosynthesis enzymes in vitro by analogues of high-energy carbocationic intermediates.

A Rahier¹, M Taton, P Benveniste.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 2185086 DOI： 10.1042/bst0180048

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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7 in total

1. New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

Authors: Ludovic Gros; Victor Manuel Castillo-Acosta; Carmen Jiménez Jiménez; Marco Sealey-Cardona; Sofia Vargas; Antonio Manuel Estévez; Vanessa Yardley; Lauren Rattray; Simon L Croft; Luis M Ruiz-Perez; Julio A Urbina; Ian H Gilbert; Dolores González-Pacanowska
Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

Review 2. Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors: N H Georgopapadakou; T J Walsh
Journal: Antimicrob Agents Chemother Date: 1996-02 Impact factor: 5.191

3. 2-azapinanes: aza analogues of the enantiomeric pinyl carbocation intermediates in pinene biosynthesis.

Authors: Juan A Faraldos; Benson M Kariuki; Robert M Coates
Journal: Org Lett Date: 2011-01-24 Impact factor: 6.005

4. 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana.

Authors: Arnab Roy; Frank G Roberts; P Ross Wilderman; Ke Zhou; Reuben J Peters; Robert M Coates
Journal: J Am Chem Soc Date: 2007-09-25 Impact factor: 15.419

Inhibition of sterol biosynthesis enzymes in vitro by analogues of high-energy carbocationic intermediates.

1. New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

Review 2. Antifungal agents: chemotherapeutic targets and immunologic strategies.

3. 2-azapinanes: aza analogues of the enantiomeric pinyl carbocation intermediates in pinene biosynthesis.

4. 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana.

Review 5. Sterol biosynthesis inhibitors: their current status and modes of action.

6. 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors.

7. General resistance to sterol biosynthesis inhibitors in Saccharomyces cerevisiae.