Literature DB >> 8649379

The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae.

S Silve1, P Leplatois, A Josse, P H Dupuy, C Lanau, M Kaghad, C Dhers, C Picard, A Rahier, M Taton, G Le Fur, D Caput, P Ferrara, G Loison.   

Abstract

SR 31747 is a novel immunosuppressant agent that arrests cell proliferation in the yeast Saccharomyces cerevisiae, SR 31747-treated cells accumulate the same aberrant sterols as those found in a mutant impaired in delta 8- delta 7-sterol isomerase. Sterol isomerase activity is also inhibited by SR 31747 in in vitro assays. Overexpression of the sterol isomerase-encoding gene, ERG2, confers enhanced SR resistance. Cells growing anaerobically on ergosterol-containing medium are not sensitive to SR. Disruption of the sterol isomerase-encoding gene is lethal in cells growing in the absence of exogenous ergosterol, except in SR-resistant mutants lacking either the SUR4 or the FEN1 gene product. The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.

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Year:  1996        PMID： 8649379      PMCID： PMC231262          DOI： 10.1128/MCB.16.6.2719

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  36 in total

1.  Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium.

Authors:  A A ANDREASEN; T J B STIER
Journal:  J Cell Comp Physiol       Date:  1953-02

2.  Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.

Authors:  P Plateau; M Fromant; J M Schmitter; J M Buhler; S Blanquet
Journal:  J Bacteriol       Date:  1989-12       Impact factor: 3.490

3.  Sterol effects on phospholipid biosynthesis in the yeast strain GL7.

Authors:  M Ramgopal; M Zundel; K Bloch
Journal:  J Lipid Res       Date:  1990-04       Impact factor: 5.922

4.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

5.  In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal property.

Authors:  C Marcireau; M Guilloton; F Karst
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

6.  Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction.

Authors:  M Taton; P Benveniste; A Rahier
Journal:  Eur J Biochem       Date:  1989-11-20

7.  FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.

Authors:  J Heitman; N R Movva; P C Hiestand; M N Hall
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

8.  Transformation of intact yeast cells treated with alkali cations.

Authors:  H Ito; Y Fukuda; K Murata; A Kimura
Journal:  J Bacteriol       Date:  1983-01       Impact factor: 3.490

9.  Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae.

Authors:  R T Lorenz; W M Casey; L W Parks
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490

10.  A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterol.

Authors:  C Dahl; H P Biemann; J Dahl
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205
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  23 in total

1.  hydra Mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling.

Authors:  Martin Souter; Jennifer Topping; Margaret Pullen; Jiri Friml; Klaus Palme; Rachel Hackett; Don Grierson; Keith Lindsey
Journal:  Plant Cell       Date:  2002-05       Impact factor: 11.277

2.  Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.

Authors:  Sarit Markovich; Aya Yekutiel; Itamar Shalit; Yona Shadkchan; Nir Osherov
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

3.  Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups.

Authors:  S D Stock; H Hama; J A Radding; D A Young; J Y Takemoto
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

4.  A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast.

Authors:  Marlis Eisenkolb; Christoph Zenzmaier; Erich Leitner; Roger Schneiter
Journal:  Mol Biol Cell       Date:  2002-12       Impact factor: 4.138

5.  A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle.

Authors:  Walid Al-Feel; James C DeMar; Salih J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

6.  Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2.

Authors:  Claire M Hull; Oliver Bader; Josie E Parker; Michael Weig; Uwe Gross; Andrew G S Warrilow; Diane E Kelly; Steven L Kelly
Journal:  Antimicrob Agents Chemother       Date:  2012-10-01       Impact factor: 5.191

7.  Yeast sphingolipids do not need to contain very long chain fatty acids.

Authors:  Vanessa Cerantola; Christine Vionnet; Olivier F Aebischer; Titus Jenny; Jens Knudsen; Andreas Conzelmann
Journal:  Biochem J       Date:  2007-01-01       Impact factor: 3.857

8.  Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.

Authors:  S D Kohlwein; S Eder; C S Oh; C E Martin; K Gable; D Bacikova; T Dunn
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

9.  Synthetically lethal interactions involving loss of the yeast ERG24: the sterol C-14 reductase gene.

Authors:  M Shah Alam Bhuiyan; James Eckstein; Robert Barbuch; Martin Bard
Journal:  Lipids       Date:  2006-12-19       Impact factor: 1.880

10.  A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster.

Authors:  Thomas Chertemps; Line Duportets; Carole Labeur; Ryu Ueda; Kuniaki Takahashi; Kaoru Saigo; Claude Wicker-Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-06       Impact factor: 11.205
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