PURPOSE: To evaluate contrast accumulation in left ventricular (LV) myocardium after manganese dipyridoxyl-diphosphate (MnDPDP) administration in patients with recent first time myocardial infarction. MATERIALS AND METHODS: MnDPDP (5 micromol/kg) was administered to 10 patients with recent myocardial infarction (three to 12 weeks). One slice of interest (SOI) likely to traverse the infarction was chosen, and sectorial pre- and postcontrast longitudinal relaxivity rates (R(1)) and signal changes during infusion were estimated with a fast gradient echo sequence. LV volume and wall thickening were measured in short-axis cine recordings. Infarct localization from R(1) and wall thickening data were compared by vector analyses. RESULTS: Reduced wall thickening was associated with reduced precontrast R(1) and reduced contrast enhancement. Both remote and infarcted regions showed rapid initial contrast accumulation. In remote regions, this was followed by a continuing slow increase. Mean precontrast R(1) was 0.87 +/- 0.06 second(-1) in infarcted regions and 0.96 +/- 0.03 second(-1) in remote regions (P < 0.001). Mean R(1) change over one hour was 0.24 +/- 0.07 second(-1) in infarcted regions and 0.38 +/- 0.03 second(-1) in remote regions (P < 0.0001). CONCLUSION: Remote regions showed larger increases in R(1) than infarcted regions. This is most likely due to selective and slow Mn accumulation in viable myocytes.
PURPOSE: To evaluate contrast accumulation in left ventricular (LV) myocardium after manganese dipyridoxyl-diphosphate (MnDPDP) administration in patients with recent first time myocardial infarction. MATERIALS AND METHODS:MnDPDP (5 micromol/kg) was administered to 10 patients with recent myocardial infarction (three to 12 weeks). One slice of interest (SOI) likely to traverse the infarction was chosen, and sectorial pre- and postcontrast longitudinal relaxivity rates (R(1)) and signal changes during infusion were estimated with a fast gradient echo sequence. LV volume and wall thickening were measured in short-axis cine recordings. Infarct localization from R(1) and wall thickening data were compared by vector analyses. RESULTS: Reduced wall thickening was associated with reduced precontrast R(1) and reduced contrast enhancement. Both remote and infarcted regions showed rapid initial contrast accumulation. In remote regions, this was followed by a continuing slow increase. Mean precontrast R(1) was 0.87 +/- 0.06 second(-1) in infarcted regions and 0.96 +/- 0.03 second(-1) in remote regions (P < 0.001). Mean R(1) change over one hour was 0.24 +/- 0.07 second(-1) in infarcted regions and 0.38 +/- 0.03 second(-1) in remote regions (P < 0.0001). CONCLUSION: Remote regions showed larger increases in R(1) than infarcted regions. This is most likely due to selective and slow Mn accumulation in viable myocytes.
Authors: Galit Saar; Corina M Millo; Lawrence P Szajek; Jeff Bacon; Peter Herscovitch; Alan P Koretsky Journal: Mol Imaging Biol Date: 2018-08 Impact factor: 3.488
Authors: Juliano L Fernandes; Pippa Storey; Jose Alvaro da Silva; Gabriel S de Figueiredo; Jose M Kalaf; Otavio R Coelho Journal: J Cardiovasc Magn Reson Date: 2011-01-14 Impact factor: 5.364
Authors: N B Spath; D M L Lilburn; G A Gray; L M Le Page; G Papanastasiou; R J Lennen; R L Janiczek; M R Dweck; D E Newby; P C Yang; M A Jansen; S I Semple Journal: Contrast Media Mol Imaging Date: 2018-10-25 Impact factor: 3.161
Authors: Nick B Spath; Trisha Singh; Giorgos Papanastasiou; Andrew Baker; Rob J Janiczek; Gerry P McCann; Marc R Dweck; Lucy Kershaw; David E Newby; Scott Semple Journal: Open Heart Date: 2021-06