Literature DB >> 20816906

Methods to assess stem cell lineage, fate and function.

Patricia K Nguyen1, Divya Nag, Joseph C Wu.   

Abstract

Stem cell therapy has the potential to regenerate injured tissue. For stem cells to achieve their full therapeutic potential, stem cells must differentiate into the target cell, reach the site of injury, survive, and engraft. To fully characterize these cells, evaluation of cell morphology, lineage specific markers, cell specific function, and gene expression must be performed. To monitor survival and engraftment, cell fate imaging is vital. Only then can organ specific function be evaluated to determine the effectiveness of therapy. In this review, we will discuss methods for evaluating the function of transplanted cells for restoring the heart, nervous system, and pancreas. We will also highlight the specific challenges facing these potential therapeutic areas.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20816906      PMCID： PMC3078641          DOI： 10.1016/j.addr.2010.08.008

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  82 in total

1.  Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency.

Authors:  Bao-Yang Hu; Jason P Weick; Junying Yu; Li-Xiang Ma; Xiao-Qing Zhang; James A Thomson; Su-Chun Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205

2.  Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.

Authors:  Marcel M Daadi; Zongjin Li; Ahmet Arac; Brad A Grueter; Marc Sofilos; Robert C Malenka; Joseph C Wu; Gary K Steinberg
Journal:  Mol Ther       Date:  2009-05-12       Impact factor: 11.454

3.  Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.

Authors:  Alexey Kuzmenkin; Huamin Liang; Guoxing Xu; Kurt Pfannkuche; Hardy Eichhorn; Azra Fatima; Hongyan Luo; Tomo Saric; Marius Wernig; Rudolf Jaenisch; Juergen Hescheler
Journal:  FASEB J       Date:  2009-08-24       Impact factor: 5.191

Review 4.  Near-infrared fluorescence: application to in vivo molecular imaging.

Authors:  Scott A Hilderbrand; Ralph Weissleder
Journal:  Curr Opin Chem Biol       Date:  2009-10-30       Impact factor: 8.822

5.  Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells.

Authors:  Zhumur Ghosh; Kitchener D Wilson; Yi Wu; Shijun Hu; Thomas Quertermous; Joseph C Wu
Journal:  PLoS One       Date:  2010-02-01       Impact factor: 3.240

6.  Long term non-invasive imaging of embryonic stem cells using reporter genes.

Authors:  Ning Sun; Andrew Lee; Joseph C Wu
Journal:  Nat Protoc       Date:  2009-07-23       Impact factor: 13.491

7.  Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.

Authors:  Ian Y Chen; Joan M Greve; Olivier Gheysens; Jürgen K Willmann; Martin Rodriguez-Porcel; Pauline Chu; Ahmad Y Sheikh; Anthony Z Faranesh; Ramasamy Paulmurugan; Phillip C Yang; Joseph C Wu; Sanjiv S Gambhir
Journal:  Mol Imaging Biol       Date:  2008-11-25       Impact factor: 3.488

Review 8.  Current status of islet cell replacement and regeneration therapy.

Authors:  Philippe A Halban; Michael S German; Steven E Kahn; Gordon C Weir
Journal:  J Clin Endocrinol Metab       Date:  2010-01-08       Impact factor: 5.958

9.  Serial noninvasive in vivo positron emission tomographic tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression.

Authors:  Mariann Gyöngyösi; Jeronimo Blanco; Teréz Marian; Lajos Trón; Ors Petneházy; Zsolt Petrasi; Rayyan Hemetsberger; Julio Rodriguez; Gusztáv Font; Imre J Pavo; István Kertész; László Balkay; Noemi Pavo; Aniko Posa; Miklos Emri; László Galuska; Dara L Kraitchman; Johann Wojta; Kurt Huber; Dietmar Glogar
Journal:  Circ Cardiovasc Imaging       Date:  2008-07-30       Impact factor: 7.792

10.  Direct conversion of fibroblasts to functional neurons by defined factors.

Authors:  Thomas Vierbuchen; Austin Ostermeier; Zhiping P Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Journal:  Nature       Date:  2010-01-27       Impact factor: 49.962
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  14 in total

Review 1.  In vivo imaging of embryonic stem cell therapy.

Authors:  Han Jiang; Zhen Cheng; Mei Tian; Hong Zhang
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-11-24       Impact factor: 9.236

2.  Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales.

Authors:  G Kate Park; Jeong Heon Lee; Andrew Levitz; Georges El Fakhri; Nathaniel S Hwang; Maged Henary; Hak Soo Choi
Journal:  Adv Mater       Date:  2019-02-10       Impact factor: 30.849

3.  Stem cell tracking with optically active nanoparticles.

Authors:  Yu Gao; Yan Cui; Jerry Ky Chan; Chenjie Xu
Journal:  Am J Nucl Med Mol Imaging       Date:  2013-04-09

4.  Cardiac differentiation of cardiosphere-derived cells in scaffolds mimicking morphology of the cardiac extracellular matrix.

Authors:  Yanyi Xu; Sourav Patnaik; Xiaolei Guo; Zhenqing Li; Wilson Lo; Ryan Butler; Andrew Claude; Zhenguo Liu; Ge Zhang; Jun Liao; Peter M Anderson; Jianjun Guan
Journal:  Acta Biomater       Date:  2014-04-24       Impact factor: 8.947

Review 5.  Nanoparticle-based monitoring of cell therapy.

Authors:  Chenjie Xu; Luye Mu; Isaac Roes; David Miranda-Nieves; Matthias Nahrendorf; James A Ankrum; Weian Zhao; Jeffrey M Karp
Journal:  Nanotechnology       Date:  2011-11-21       Impact factor: 3.874

6.  Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys.

Authors:  Alice F Tarantal; C Chang I Lee; Cynthia A Batchelder; Jared E Christensen; Daniel Prater; Simon R Cherry
Journal:  Mol Imaging Biol       Date:  2012-04       Impact factor: 3.488

Review 7.  Magnetic resonance imaging of transplanted stem cell fate in stroke.

Authors:  Hamid Reza Aghayan; Masoud Soleimani; Parisa Goodarzi; Abbas Norouzi-Javidan; Seyed Hasan Emami-Razavi; Bagher Larijani; Babak Arjmand
Journal:  J Res Med Sci       Date:  2014-05       Impact factor: 1.852

Review 8.  Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.

Authors:  James A Heslop; Thomas G Hammond; Ilaria Santeramo; Agnès Tort Piella; Isabel Hopp; Jing Zhou; Roua Baty; Enrique I Graziano; Bernabé Proto Marco; Alexis Caron; Patrik Sköld; Peter W Andrews; Melissa A Baxter; David C Hay; Junnat Hamdam; Michaela E Sharpe; Sara Patel; David R Jones; Jens Reinhardt; Erik H J Danen; Uri Ben-David; Glyn Stacey; Petter Björquist; Jacqueline Piner; John Mills; Cliff Rowe; Giovanni Pellegrini; Swaminathan Sethu; Daniel J Antoine; Michael J Cross; Patricia Murray; Dominic P Williams; Neil R Kitteringham; Chris E P Goldring; B Kevin Park
Journal:  Stem Cells Transl Med       Date:  2015-02-26       Impact factor: 6.940

9.  Tracking the Fate of Muscle-derived Stem Cells: an Insight into the Distribution and Mode of Action.

Authors:  Hyung Sub Park; Geum Hee Choi; Soli Hahn; Young Sun Yoo; In Mok Jung; Taeseung Lee
Journal:  Vasc Specialist Int       Date:  2014-03-30

Review 10.  Commercial nanoparticles for stem cell labeling and tracking.

Authors:  Yaqi Wang; Chenjie Xu; Hooisweng Ow
Journal:  Theranostics       Date:  2013-07-20       Impact factor: 11.556
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