Literature DB >> 17670931

Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation.

Tao Hong1, Xiangyang Li, Jie Wang, Cynthia Sloan, Cristina Cicogna.   

Abstract

We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 microg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mutation. This is the first report of the failure of linezolid treatment for Staphylococcus epidermidis bacteremia associated with a G2576T mutation in an immunocompromised patient.

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Year:  2007        PMID： 17670931      PMCID： PMC2045370          DOI： 10.1128/JCM.02048-06

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

1.  Linezolid resistance in clinical isolates of Staphylococcus aureus.

Authors:  Peter Wilson; J A Andrews; R Charlesworth; R Walesby; M Singer; D J Farrell; M Robbins
Journal:  J Antimicrob Chemother       Date:  2003-01       Impact factor: 5.790

2.  Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.

Authors:  S H Marshall; C J Donskey; R Hutton-Thomas; R A Salata; L B Rice
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

3.  Identification of bacteria in formalin-fixed, paraffin-embedded heart valve tissue via 16S rRNA gene nucleotide sequencing.

Authors:  Kavita Imrit; Michael Goldfischer; Jie Wang; Jaime Green; Jerome Levine; Joseph Lombardo; Tao Hong
Journal:  J Clin Microbiol       Date:  2006-07       Impact factor: 5.948

4.  Trends in linezolid susceptibility patterns: report from the 2002-2003 worldwide Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) Program.

Authors:  Tamara R Anderegg; Helio S Sader; Thomas R Fritsche; James E Ross; Ronald N Jones
Journal:  Int J Antimicrob Agents       Date:  2005-07       Impact factor: 5.283

5.  Epidemiological profile of linezolid-resistant coagulase-negative staphylococci.

Authors:  Brian A Potoski; Jennifer Adams; Lloyd Clarke; Kathleen Shutt; Peter K Linden; Carla Baxter; A William Pasculle; Blair Capitano; Anton Y Peleg; Dora Szabo; David L Paterson
Journal:  Clin Infect Dis       Date:  2006-06-05       Impact factor: 9.079

6.  Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.

Authors:  Steven R Gill; Derrick E Fouts; Gordon L Archer; Emmanuel F Mongodin; Robert T Deboy; Jacques Ravel; Ian T Paulsen; James F Kolonay; Lauren Brinkac; Mauren Beanan; Robert J Dodson; Sean C Daugherty; Ramana Madupu; Samuel V Angiuoli; A Scott Durkin; Daniel H Haft; Jessica Vamathevan; Hoda Khouri; Terry Utterback; Chris Lee; George Dimitrov; Lingxia Jiang; Haiying Qin; Jan Weidman; Kevin Tran; Kathy Kang; Ioana R Hance; Karen E Nelson; Claire M Fraser
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

7.  Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors:  L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

8.  Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.

Authors:  Satish K Pillai; George Sakoulas; Christine Wennersten; George M Eliopoulos; Robert C Moellering; Mary Jane Ferraro; Howard S Gold
Journal:  J Infect Dis       Date:  2002-11-04       Impact factor: 5.226

9.  Use of pyrosequencing to identify point mutations in domain V of 23S rRNA genes of linezolid-resistant Staphylococcus aureus and Staphylococcus epidermidis.

Authors:  W Zhu; F C Tenover; J Limor; D Lonsway; D Prince; W M Dunne; J B Patel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-03       Impact factor: 3.267

10.  Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).

Authors:  Yue-Qing Zhang; Shuang-Xi Ren; Hua-Lin Li; Yong-Xiang Wang; Gang Fu; Jian Yang; Zhi-Qiang Qin; You-Gang Miao; Wen-Yi Wang; Run-Sheng Chen; Yan Shen; Zhu Chen; Zheng-Hong Yuan; Guo-Ping Zhao; Di Qu; Antoine Danchin; Yu-Mei Wen
Journal:  Mol Microbiol       Date:  2003-09       Impact factor: 3.501
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  10 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr.

Authors:  Mercedes Marín; Adoración Martín; Luis Alcalá; Emilia Cercenado; Cristina Iglesias; Elena Reigadas; Emilio Bouza
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

3.  Endemic linezolid-resistant Staphylococcus epidermidis in a critical care unit.

Authors:  M Treviño; L Martínez-Lamas; P A Romero-Jung; J M Giráldez; J Alvarez-Escudero; B J Regueiro
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2008-11-05       Impact factor: 3.267

4.  Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.

Authors:  Jie Feng; Andréanne Lupien; Hélène Gingras; Jessica Wasserscheid; Ken Dewar; Danielle Légaré; Marc Ouellette
Journal:  Genome Res       Date:  2009-04-06       Impact factor: 9.043

5.  Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unit.

Authors:  A Sorlozano; J Gutierrez; T Martinez; M E Yuste; J A Perez-Lopez; A Vindel; J Guillen; T Boquete
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-10-30       Impact factor: 3.267

6.  Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans.

Authors:  Lanqing Cui; Yang Wang; Yun Li; Tao He; Stefan Schwarz; Yujing Ding; Jianzhong Shen; Yuan Lv
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

7.  Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

Authors:  Dewan S Billal; Jie Feng; Philippe Leprohon; Danielle Légaré; Marc Ouellette
Journal:  BMC Genomics       Date:  2011-10-17       Impact factor: 3.969

8.  Linezolid resistant coagulase negative staphylococci (LRCoNS) with novel mutations causing blood stream infections (BSI) in India.

Authors:  Gajanand Mittal; Vasundhra Bhandari; Rajni Gaind; Vandana Rani; Shimpi Chopra; Reetika Dawar; Raman Sardana; P K Verma
Journal:  BMC Infect Dis       Date:  2019-08-14       Impact factor: 3.090

Review 9.  The emerging problem of linezolid-resistant Staphylococcus.

Authors:  Bing Gu; Theodoros Kelesidis; Sotirios Tsiodras; Janet Hindler; Romney M Humphries
Journal:  J Antimicrob Chemother       Date:  2012-09-04       Impact factor: 5.758

10.  Molecular epidemiology of coagulase-negative bloodstream isolates: detection of Staphylococcus epidermidis ST2, ST7 and linezolid-resistant ST23.

Authors:  Adrián Martínez-Meléndez; Rayo Morfín-Otero; Licet Villarreal-Treviño; Adrián Camacho-Ortíz; Gloria González-González; Jorge Llaca-Díaz; Eduardo Rodríguez-Noriega; Elvira Garza-González
Journal:  Braz J Infect Dis       Date:  2016-07-06       Impact factor: 3.257
  10 in total

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