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Literature DB >> 19738021

Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.

Güliz Gürel¹, Gregor Blaha, Thomas A Steitz, Peter B Moore.

Abstract

Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.

Entities: Chemical Species

Mesh：

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Year: 2009 PMID： 19738021 PMCID： PMC2786347 DOI： 10.1128/AAC.00817-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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