AIMS: The aim of the present study was to assess the clinical performance of a dual X-ray source multi-slice CT (MSCT) with high temporal resolution to assess the coronary status in patients with an intermediate pretest likelihood for significant coronary artery disease (CAD) without using negative chronotropic pretreatment. METHODS AND RESULTS: Dual-source CT (DSCT) angiography (Siemens Definition) was performed in 90 patients with an intermediate likelihood for CAD who were referred for invasive coronary angiography. DSCT generated data sets with diagnostic image quality in 88 of the overall 90 patients. In six of seven patients with atrial fibrillation and in 46 of 48 patients with heart rates (HR)>65 b.p.m. image quality was diagnostic. In 20 of 21 patients with at least one stenosis>50% (sensitivity 95%) were correctly identified by DSCT-angiography. In 60 of 67 patients, a lesion>50% was correctly excluded (specificity 90%; positive predictive value 74%). The accuracy to detect patients with coronary stenoses>50% (sensitivity 92 vs. 100%; specificity 88 vs. 91%) was not significantly different among patients with HR>65 b.p.m. (n=46) and <65 b.p.m. The concordance of DSCT-derived stenosis quantification showed good correlation (r=0.76; P<0.001) to quantitative coronary angiography with a slight trend to overestimate the stenosis degree. CONCLUSION: DSCT is a non-invasive tool that allows to accurately rule out coronary stenoses in patients with an intermediate pretest likelihood for CAD, independent of the HR.
AIMS: The aim of the present study was to assess the clinical performance of a dual X-ray source multi-slice CT (MSCT) with high temporal resolution to assess the coronary status in patients with an intermediate pretest likelihood for significant coronary artery disease (CAD) without using negative chronotropic pretreatment. METHODS AND RESULTS: Dual-source CT (DSCT) angiography (Siemens Definition) was performed in 90 patients with an intermediate likelihood for CAD who were referred for invasive coronary angiography. DSCT generated data sets with diagnostic image quality in 88 of the overall 90 patients. In six of seven patients with atrial fibrillation and in 46 of 48 patients with heart rates (HR)>65 b.p.m. image quality was diagnostic. In 20 of 21 patients with at least one stenosis>50% (sensitivity 95%) were correctly identified by DSCT-angiography. In 60 of 67 patients, a lesion>50% was correctly excluded (specificity 90%; positive predictive value 74%). The accuracy to detect patients with coronary stenoses>50% (sensitivity 92 vs. 100%; specificity 88 vs. 91%) was not significantly different among patients with HR>65 b.p.m. (n=46) and <65 b.p.m. The concordance of DSCT-derived stenosis quantification showed good correlation (r=0.76; P<0.001) to quantitative coronary angiography with a slight trend to overestimate the stenosis degree. CONCLUSION: DSCT is a non-invasive tool that allows to accurately rule out coronary stenoses in patients with an intermediate pretest likelihood for CAD, independent of the HR.
Authors: Cynthia H McCollough; Bernhard Schmidt; Lifeng Yu; Andrew Primak; Stefan Ulzheimer; Herbert Bruder; Thomas G Flohr Journal: Med Phys Date: 2008-02 Impact factor: 4.071
Authors: Robert Roehle; Viktoria Wieske; Georg M Schuetz; Pascal Gueret; Daniele Andreini; Willem Bob Meijboom; Gianluca Pontone; Mario Garcia; Hatem Alkadhi; Lily Honoris; Jörg Hausleiter; Nuno Bettencourt; Elke Zimmermann; Sebastian Leschka; Bernhard Gerber; Carlos Rochitte; U Joseph Schoepf; Abbas Arjmand Shabestari; Bjarne Nørgaard; Akira Sato; Juhani Knuuti; Matthijs F L Meijs; Harald Brodoefel; Shona M M Jenkins; Kristian Altern Øvrehus; Axel Cosmus Pyndt Diederichsen; Ashraf Hamdan; Bjørn Arild Halvorsen; Vladimir Mendoza Rodriguez; Yung Liang Wan; Johannes Rixe; Mehraj Sheikh; Christoph Langer; Said Ghostine; Eugenio Martuscelli; Hiroyuki Niinuma; Arthur Scholte; Konstantin Nikolaou; Geir Ulimoen; Zhaoqi Zhang; Hans Mickley; Koen Nieman; Philipp A Kaufmann; Ronny Ralf Buechel; Bernhard A Herzog; Melvin Clouse; David A Halon; Jonathan Leipsic; David Bush; Reda Jakamy; Kai Sun; Lin Yang; Thorsten Johnson; Jean-Pierre Laissy; Roy Marcus; Simone Muraglia; Jean-Claude Tardif; Benjamin Chow; Narinder Paul; David Maintz; John Hoe; Albert de Roos; Robert Haase; Michael Laule; Peter Schlattmann; Marc Dewey Journal: Eur Radiol Date: 2018-03-19 Impact factor: 5.315
Authors: Julie M Miller; Marc Dewey; Andrea L Vavere; Carlos E Rochitte; Hiroyuki Niinuma; Armin Arbab-Zadeh; Narinder Paul; John Hoe; Albert de Roos; Kunihiro Yoshioka; Pedro A Lemos; David E Bush; Albert C Lardo; John Texter; Jeffery Brinker; Christopher Cox; Melvin E Clouse; João A C Lima Journal: Eur Radiol Date: 2008-11-08 Impact factor: 5.315