| Literature DB >> 17644583 |
Elise Darmon1, Manuel A Lopez-Vernaza, Anne C Helness, Amanda Borking, Emily Wilson, Zubin Thacker, Laura Wardrope, David R F Leach.
Abstract
The SbcCD complex and its homologues play important roles in DNA repair and in the maintenance of genome stability. In Escherichia coli, the in vitro functions of SbcCD have been well characterized, but its exact cellular role remains elusive. This work investigates the regulation of the sbcDC operon and the cellular localization of the SbcC and SbcD proteins. Transcription of the sbcDC operon is shown to be dependent on starvation and RpoS protein. Overexpressed SbcC protein forms foci that colocalize with the replication factory, while overexpressed SbcD protein is distributed through the cytoplasm.Entities:
Mesh:
Substances:
Year: 2007 PMID: 17644583 PMCID: PMC2045166 DOI: 10.1128/JB.00489-07
Source DB: PubMed Journal: J Bacteriol ISSN: 0021-9193 Impact factor: 3.490