Literature DB >> 17644292

Huperzine A from Huperzia species--an ethnopharmacolgical review.

Xiaoqiang Ma1, Changheng Tan, Dayuan Zhu, David R Gang, Peigen Xiao.   

Abstract

Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.

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Year:  2007        PMID： 17644292     DOI： 10.1016/j.jep.2007.05.030

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  42 in total

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Review 2.  Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia.

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5.  Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia.

Authors:  Daniel Cuthbertson; Jasenka Piljac-Žegarac; Bernd Markus Lange
Journal:  Biomed Chromatogr       Date:  2012-01-24       Impact factor: 1.902

Review 6.  Neurotrophic natural products: chemistry and biology.

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7.  Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.

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Journal:  J Ind Microbiol Biotechnol       Date:  2014-05-28       Impact factor: 3.346

Review 8.  A review of the use of pteridophytes for treating human ailments.

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Journal:  J Zhejiang Univ Sci B       Date:  2018 Feb.       Impact factor: 3.066

9.  Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis.

Authors:  Somnuk Bunsupa; Kousuke Hanada; Akira Maruyama; Kaori Aoyagi; Kana Komatsu; Hideki Ueno; Madoka Yamashita; Ryosuke Sasaki; Akira Oikawa; Kazuki Saito; Mami Yamazaki
Journal:  Plant Physiol       Date:  2016-06-14       Impact factor: 8.340

10.  Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China.

Authors:  Ya Wang; Zheng Lai; Xi-Xi Li; Ri-Ming Yan; Zhi-Bin Zhang; Hui-Lin Yang; Du Zhu
Journal:  World J Microbiol Biotechnol       Date:  2016-01-08       Impact factor: 3.312
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