Literature DB >> 21072430

Natural products as a source of Alzheimer's drug leads.

Philip Williams1, Analia Sorribas, Melanie-Jayne R Howes.   

Abstract

This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than 180 compounds and summarizes 400 references.

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Year:  2010        PMID： 21072430      PMCID： PMC4917364          DOI： 10.1039/c0np00027b

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  348 in total

1.  Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo.

Authors:  N S L Perry; P J Houghton; P Jenner; A Keith; E K Perry
Journal:  Phytomedicine       Date:  2002-01       Impact factor: 5.340

2.  Causes and consequences of oxidative stress in Alzheimer's disease.

Authors:  Mark A Smith; George Perry; William A Pryor
Journal:  Free Radic Biol Med       Date:  2002-06-01       Impact factor: 7.376

3.  Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

Authors:  Ester Angulo; Véronique Noé; Vicent Casadó; Josefa Mallol; Teresa Gomez-Isla; Carmen Lluis; Isidre Ferrer; Carlos J Ciudad; Rafael Franco
Journal:  J Neurochem       Date:  2004-11       Impact factor: 5.372

4.  Beta-secretase (BACE1)-inhibiting stilbenoids from Smilax Rhizoma.

Authors:  S-Y Jeon; S-H Kwon; Y-H Seong; K Bae; J-M Hur; Y-Y Lee; D-Y Suh; K-S Song
Journal:  Phytomedicine       Date:  2006-11-03       Impact factor: 5.340

5.  Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase.

Authors:  Moustapha Alfa Cissé; Céline Gandreuil; Jean-François Hernandez; Jean Martinez; Frédéric Checler; Bruno Vincent
Journal:  Biochem Biophys Res Commun       Date:  2006-06-21       Impact factor: 3.575

6.  Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.

Authors:  Kenjiro Ono; Kazuhiro Hasegawa; Hironobu Naiki; Masahito Yamada
Journal:  Biochim Biophys Acta       Date:  2004-11-05

7.  Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids.

Authors:  Mitsuo Miyazawa; Chikako Yamafuji
Journal:  J Agric Food Chem       Date:  2005-03-09       Impact factor: 5.279

8.  Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.

Authors:  René Etcheberrigaray; Mathew Tan; Ilse Dewachter; Cuno Kuipéri; Ingrid Van der Auwera; Stefaan Wera; Lixin Qiao; Barry Bank; Thomas J Nelson; Alan P Kozikowski; Fred Van Leuven; Daniel L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-19       Impact factor: 11.205

9.  GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Authors:  Christopher J Phiel; Christina A Wilson; Virginia M-Y Lee; Peter S Klein
Journal:  Nature       Date:  2003-05-22       Impact factor: 49.962

Review 10.  Progress toward a practical BACE-1 inhibitor.

Authors:  Ivory D Hills; Joseph P Vacca
Journal:  Curr Opin Drug Discov Devel       Date:  2007-07
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  63 in total

Review 1.  The role of phytochemicals in the treatment and prevention of dementia.

Authors:  Melanie-Jayne R Howes; Elaine Perry
Journal:  Drugs Aging       Date:  2011-06-01       Impact factor: 3.923

2.  Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1.

Authors:  Jingqiu Dai; Dai Shen; Wesley Y Yoshida; Stephen M Parrish; Philip G Williams
Journal:  Planta Med       Date:  2012-07-04       Impact factor: 3.352

3.  Neuroprotective effects of digested polyphenols from wild blackberry species.

Authors:  Lucélia Tavares; Inês Figueira; Gordon J McDougall; Helena L A Vieira; Derek Stewart; Paula M Alves; Ricardo B Ferreira; Cláudia N Santos
Journal:  Eur J Nutr       Date:  2013-02       Impact factor: 5.614

Review 4.  Neuroprotective effect of natural products against Alzheimer's disease.

Authors:  Musthafa M Essa; Reshmi K Vijayan; Gloria Castellano-Gonzalez; Mustaq A Memon; Nady Braidy; Gilles J Guillemin
Journal:  Neurochem Res       Date:  2012-05-22       Impact factor: 3.996

Review 5.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

6.  Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model.

Authors:  Chuang Guo; Zhao-Hui Yang; Shuai Zhang; Rui Chai; Han Xue; Yan-Hui Zhang; Jia-Yi Li; Zhan-You Wang
Journal:  Neuropsychopharmacology       Date:  2017-01-12       Impact factor: 7.853

7.  The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice.

Authors:  Ho Jung Bae; Jihyun Kim; Jaehoon Kim; Nayeon Goo; Mudan Cai; Kyungnam Cho; Seo Yun Jung; Huiyoung Kwon; Dong Hyun Kim; Dae Sik Jang; Jong Hoon Ryu
Journal:  Br J Pharmacol       Date:  2020-04-01       Impact factor: 8.739

8.  Natural Modulators of Amyloid-Beta Precursor Protein Processing.

Authors:  C Zhang; R E Tanzi
Journal:  Curr Alzheimer Res       Date:  2012-09-13       Impact factor: 3.498

9.  Oleuropein, an anti-oxidant polyphenol constituent of olive promotes α-secretase cleavage of the amyloid precursor protein (AβPP).

Authors:  Myrta Kostomoiri; Apostolia Fragkouli; Marina Sagnou; Leandros A Skaltsounis; Maria Pelecanou; Effie C Tsilibary; Athina K Tzinia
Journal:  Cell Mol Neurobiol       Date:  2012-10-07       Impact factor: 5.046

10.  Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal:  Chemistry       Date:  2013-03-22       Impact factor: 5.236
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