Literature DB >> 17643113

Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.

David M Weinstock1, Erika Brunet, Maria Jasin.   

Abstract

Chromosomal translocations in lymphoid tumours can involve antigen-receptor loci undergoing V(D)J recombination. Here, we show that translocations are recovered from the joining of RAG-generated double-strand breaks (DSBs) on one chromosome to an endonuclease-generated DSB on a second chromosome, providing evidence for the participation of non-RAG DSBs in some lymphoid translocations. Surprisingly, translocations are increased in cells deficient for the nonhomologous end-joining (NHEJ) protein Ku70, implicating non-canonical joining pathways in their etiology.

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Year:  2007        PMID： 17643113      PMCID： PMC3065497          DOI： 10.1038/ncb1624

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  12 in total

Review 1.  The mechanism and regulation of chromosomal V(D)J recombination.

Authors:  Craig H Bassing; Wojciech Swat; Frederick W Alt
Journal:  Cell       Date:  2002-04       Impact factor: 41.582

2.  Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.

Authors:  Nicole S Verkaik; Rebecca E E Esveldt-van Lange; Diana van Heemst; Hennie T Brüggenwirth; Jan H J Hoeijmakers; Malgorzata Z Zdzienicka; Dik C van Gent
Journal:  Eur J Immunol       Date:  2002-03       Impact factor: 5.532

3.  Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors:  Y Gu; S Jin; Y Gao; D T Weaver; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

4.  Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

Authors:  Chengming Zhu; Kevin D Mills; David O Ferguson; Charles Lee; John Manis; James Fleming; Yijie Gao; Cynthia C Morton; Frederick W Alt
Journal:  Cell       Date:  2002-06-28       Impact factor: 41.582

Review 5.  Mechanism and regulation of human non-homologous DNA end-joining.

Authors:  Michael R Lieber; Yunmei Ma; Ulrich Pannicke; Klaus Schwarz
Journal:  Nat Rev Mol Cell Biol       Date:  2003-09       Impact factor: 94.444

Review 6.  Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations.

Authors:  Michael R Lieber; Kefei Yu; Sathees C Raghavan
Journal:  DNA Repair (Amst)       Date:  2006-06-21

Review 7.  Restraining the V(D)J recombinase.

Authors:  David B Roth
Journal:  Nat Rev Immunol       Date:  2003-08       Impact factor: 53.106

8.  A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair.

Authors:  David M Weinstock; Beth Elliott; Maria Jasin
Journal:  Blood       Date:  2005-09-29       Impact factor: 22.113

9.  Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

Authors:  F Liang; M Jasin
Journal:  J Biol Chem       Date:  1996-06-14       Impact factor: 5.157

10.  Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.

Authors:  Michael J Difilippantonio; Simone Petersen; Hua Tang Chen; Roger Johnson; Maria Jasin; Roland Kanaar; Thomas Ried; André Nussenzweig
Journal:  J Exp Med       Date:  2002-08-19       Impact factor: 14.307
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  80 in total

1.  Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

Authors:  Anastazja Grabarz; Aurélia Barascu; Josée Guirouilh-Barbat; Bernard S Lopez
Journal:  Am J Cancer Res       Date:  2012-04-21       Impact factor: 6.166

Review 2.  Origin of chromosomal translocations in lymphoid cancer.

Authors:  André Nussenzweig; Michel C Nussenzweig
Journal:  Cell       Date:  2010-04-02       Impact factor: 41.582

Review 3.  Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

Authors:  Mary Ellen Moynahan; Maria Jasin
Journal:  Nat Rev Mol Cell Biol       Date:  2010-03       Impact factor: 94.444

4.  Mechanisms of leukemia translocations.

Authors:  Jac A Nickoloff; Leyma P De Haro; Justin Wray; Robert Hromas
Journal:  Curr Opin Hematol       Date:  2008-07       Impact factor: 3.284

Review 5.  Repair of strand breaks by homologous recombination.

Authors:  Maria Jasin; Rodney Rothstein
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-11-01       Impact factor: 10.005

6.  Parp3 promotes long-range end joining in murine cells.

Authors:  Jacob V Layer; J Patrick Cleary; Alexander J Brown; Kristen E Stevenson; Sara N Morrow; Alexandria Van Scoyk; Rafael B Blasco; Elif Karaca; Fei-Long Meng; Richard L Frock; Trevor Tivey; Sunhee Kim; Hailey Fuchs; Roberto Chiarle; Frederick W Alt; Steven A Roberts; David M Weinstock; Tovah A Day
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-13       Impact factor: 11.205

Review 7.  MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.

Authors:  Mitch McVey; Sang Eun Lee
Journal:  Trends Genet       Date:  2008-09-21       Impact factor: 11.639

Review 8.  Charity begins at home: non-coding RNA functions in DNA repair.

Authors:  Dipanjan Chowdhury; Young Eun Choi; Marie Eve Brault
Journal:  Nat Rev Mol Cell Biol       Date:  2013-02-06       Impact factor: 94.444

9.  Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells.

Authors:  Michael N Cornforth; Pavana Anur; Nicholas Wang; Erin Robinson; F Andrew Ray; Joel S Bedford; Bradford D Loucas; Eli S Williams; Myron Peto; Paul Spellman; Rahul Kollipara; Ralf Kittler; Joe W Gray; Susan M Bailey
Journal:  Radiat Res       Date:  2018-05-11       Impact factor: 2.841

10.  Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.

Authors:  Sze Ham Chan; Amy Marie Yu; Mitch McVey
Journal:  PLoS Genet       Date:  2010-07-01       Impact factor: 5.917
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