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Literature DB >> 24097900

Repair of strand breaks by homologous recombination.

Abstract

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.

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Year: 2013 PMID： 24097900 PMCID： PMC3809576 DOI： 10.1101/cshperspect.a012740

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

179 in total

1. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

Authors: Michael Lisby; Jacqueline H Barlow; Rebecca C Burgess; Rodney Rothstein
Journal: Cell Date: 2004-09-17 Impact factor: 41.582

2. RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

Authors: Gregory S Lee; Matthew B Neiditch; Sandra S Salus; David B Roth
Journal: Cell Date: 2004-04-16 Impact factor: 41.582

3. Sgs1--the maestro of recombination.

Authors: Hannah L Klein; Lorraine S Symington
Journal: Cell Date: 2012-04-13 Impact factor: 41.582

4. Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.

Authors: Zhucheng Chen; Haijuan Yang; Nikola P Pavletich
Journal: Nature Date: 2008-05-22 Impact factor: 49.962

5. The mouse Spo11 gene is required for meiotic chromosome synapsis.

Authors: P J Romanienko; R D Camerini-Otero
Journal: Mol Cell Date: 2000-11 Impact factor: 17.970

Review 6. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Authors: F Pâques; J E Haber
Journal: Microbiol Mol Biol Rev Date: 1999-06 Impact factor: 11.056

7. Gene conversion between duplicated genetic elements in yeast.

Authors: J A Jackson; G R Fink
Journal: Nature Date: 1981-07-23 Impact factor: 49.962

8. Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1.

Authors: Valerie Garcia; Sarah E L Phelps; Stephen Gray; Matthew J Neale
Journal: Nature Date: 2011-10-16 Impact factor: 49.962

9. Limiting the persistence of a chromosome break diminishes its mutagenic potential.

Authors: Nicole Bennardo; Amanda Gunn; Anita Cheng; Paul Hasty; Jeremy M Stark
Journal: PLoS Genet Date: 2009-10-16 Impact factor: 5.917

10. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Authors: Grzegorz Ira; Achille Pellicioli; Alitukiriza Balijja; Xuan Wang; Simona Fiorani; Walter Carotenuto; Giordano Liberi; Debra Bressan; Lihong Wan; Nancy M Hollingsworth; James E Haber; Marco Foiani
Journal: Nature Date: 2004-10-21 Impact factor: 49.962

331 in total

1. Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases.

Authors: Lianne E M Vriend; Maria Jasin; Przemek M Krawczyk
Journal: Methods Enzymol Date: 2014 Impact factor: 1.600

Review 2. Mechanisms of gene targeting in higher eukaryotes.

Authors: Akinori Tokunaga; Hirofumi Anai; Katsuhiro Hanada
Journal: Cell Mol Life Sci Date: 2015-10-27 Impact factor: 9.261

3. Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.

Authors: María Belén Vallerga; Sabrina F Mansilla; María Belén Federico; Agustina P Bertolin; Vanesa Gottifredi
Journal: Proc Natl Acad Sci U S A Date: 2015-11-16 Impact factor: 11.205

4. Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.

Authors: Sarah R Hengel; Eva Malacaria; Laura Folly da Silva Constantino; Fletcher E Bain; Andrea Diaz; Brandon G Koch; Liping Yu; Meng Wu; Pietro Pichierri; M Ashley Spies; Maria Spies
Journal: Elife Date: 2016-07-19 Impact factor: 8.140

10. Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.

Authors: Kara A Bernstein; Eleni P Mimitou; Michael J Mihalevic; Huan Chen; Ivana Sunjaveric; Lorraine S Symington; Rodney Rothstein
Journal: Genetics Date: 2013-10-04 Impact factor: 4.562