Literature DB >> 1764035

Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages.

E R Werner1, G Werner-Felmayer, D Fuchs, A Hausen, G Reibnegger, J J Yim, H Wachter.   

Abstract

Tumour necrosis factor-alpha causes an up to 30-fold induction of GTP cyclohydrolase I (EC 3.5.4.16) activity in murine dermal fibroblasts in a dose-dependent manner. Owing to the high constitutive activities of 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), this potentiates biosynthesis of tetrahydrobiopterin. Murine macrophages already contain high activities of GTP cyclohydrolase I when unstimulated, and this is further augmented up to 4-fold by tumour necrosis factor-alpha/interferon-gamma. In Western blots an antiserum to murine liver GTP cyclohydrolase I does not stain cell extracts with high enzyme activities, suggesting that the cytokine induced peripheral form of GTP cyclohydrolase I might differ from the liver form.

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Year:  1991        PMID： 1764035      PMCID： PMC1130511          DOI： 10.1042/bj2800709

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Isolation and characterization of GTP cyclohydrolase I from mouse liver. Comparison of normal and the hph-1 mutant.

Authors:  K W Cha; K B Jacobson; J J Yim
Journal:  J Biol Chem       Date:  1991-07-05       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Enhanced urinary excretion of 7,8-dihydro-6-hydroxylumazine by mice bearing the Ehrlich ascites tumour.

Authors:  H Wachter; K Grassmayr; A Hausen
Journal:  Cancer Lett       Date:  1979-02       Impact factor: 8.679

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses.

Authors:  W C Russell; C Newman; D H Williamson
Journal:  Nature       Date:  1975-02-06       Impact factor: 49.962

6.  Increased biopterin production in rats with tumors induced by radon inhalation and benzonaphthoflavone administration.

Authors:  P Mura; J P Morlier; M Barriere; P Bredon; Y Papet; J Chameaud
Journal:  Cancer Lett       Date:  1990-10-08       Impact factor: 8.679

7.  Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2.

Authors:  I Ziegler; K Schott; M Lübbert; F Herrmann; U Schwuléra; A Bacher
Journal:  J Biol Chem       Date:  1990-10-05       Impact factor: 5.157

8.  Characteristics of guanosine triphosphate cyclohydrolase I purified from Escherichia coli.

Authors:  J J Yim; G M Brown
Journal:  J Biol Chem       Date:  1976-08-25       Impact factor: 5.157

9.  [Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases (author's transl)].

Authors:  H Wachter; A Hausen; K Grassmayr
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1979-12

10.  Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

Authors:  G Werner-Felmayer; E R Werner; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal:  J Exp Med       Date:  1990-12-01       Impact factor: 14.307
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  6 in total

1.  Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

Authors:  P Rosenkranz-Weiss; W C Sessa; S Milstien; S Kaufman; C A Watson; J S Pober
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

2.  Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase.

Authors:  Karin L Leitner; Martina Meyer; Walter Leimbacher; Anja Peterbauer; Susanne Hofer; Christine Heufler; Angelika Müller; Regine Heller; Ernst R Werner; Beat Thöny; Gabriele Werner-Felmayer
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

Review 3.  Tetrahydrobiopterin biosynthesis, regeneration and functions.

Authors:  B Thöny; G Auerbach; N Blau
Journal:  Biochem J       Date:  2000-04-01       Impact factor: 3.857

4.  Detection of bacterial pyrogens on the basis of their effects on gamma interferon-mediated formation of neopterin or nitrite in cultured monocyte cell lines.

Authors:  G Werner-Felmayer; G Baier-Bitterlich; D Fuchs; A Hausen; C Murr; G Reibnegger; E R Werner; H Wachter
Journal:  Clin Diagn Lab Immunol       Date:  1995-05

5.  Ca2+/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180.

Authors:  G Werner-Felmayer; E R Werner; D Fuchs; A Hausen; B Mayer; G Reibnegger; G Weiss; H Wachter
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

6.  Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

Authors:  G Weiss; G Werner-Felmayer; E R Werner; K Grünewald; H Wachter; M W Hentze
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307
  6 in total

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