Literature DB >> 1763946

[Synthesis of CNS-activity of pyran derivatives: 6,8-dioxabicyclo(3,2,1)octane].

F Eiden1, F Denk.   

Abstract

The amino nitriles 4a,b and 5a,b, prepared from (1S,5R)-6,8-dioxabicyclo[3,2,1]octan-4-one (2), react with phenylmagnesium bromide to afford the diastereomeric 4-amino-4-phenyl derivatives 7a,b and 8a,b, respectively. The diastereomeric piperidine derivatives 7b and 8b show different CNS-activity.

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Year:  1991        PMID： 1763946     DOI： 10.1002/ardp.19913240606

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  7 in total

1.  Crystal structures of two 4H-chromene derivatives: 2-amino-3-cyano-4-(3,4-di-chloro-phen-yl)-7-hy-droxy-4H-benzo[1,2-b]pyran 1,4-dioxane monosolvate and 2-amino-3-cyano-4-(2,6-di-chloro-phen-yl)-7-hy-droxy-4H-benzo[1,2-b]pyran.

Authors:  S Silambarasan; A Jamal Abdul Nasser; T Mohandas
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-09-27

2.  Immobilized TiO2 nanoparticles on carbon nanotubes: an efficient heterogeneous catalyst for the synthesis of chromeno[b]pyridine derivatives under ultrasonic irradiation.

Authors:  Shahrzad Abdolmohammadi; Behrooz Mirza; Esmail Vessally
Journal:  RSC Adv       Date:  2019-12-17       Impact factor: 4.036

3.  Crystal structure of 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbo-nitrile.

Authors:  Shaaban K Mohamed; Peter N Horton; Mehmet Akkurt; Sabry H H Younes; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-06-27

4.  Crystal structure of 3-amino-1-(4-chloro-phen-yl)-1H-benzo[f]chromene-2-carbo-nitrile.

Authors:  Mehmet Akkurt; Peter N Horton; Shaaban K Mohamed; Sabry H H Younes; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-06-13

5.  Crystal structure, DFT and Hirshfeld surface analysis of 2-amino-4-(2-chloro-phen-yl)-7-hy-droxy-4H-benzo[1,2-b]pyran-3-carbo-nitrile.

Authors:  M Beemarao; S Silambarasan; A Jamal Abdul Nasser; M Purushothaman; K Ravichandran
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-22

6.  Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives.

Authors:  Ashraf H F Abd El-Wahab
Journal:  Pharmaceuticals (Basel)       Date:  2012-07-12

7.  Synthesis and antitumor activity against HepG-2, PC-3, and HCT-116 cells of some naphthyridine and pyranopyridinecarbonitrile derivatives.

Authors:  S F Mohamed; N A Abdel-Hafez; A E Amr; H M Awad
Journal:  Russ J Gen Chem       Date:  2017-08-02       Impact factor: 0.868
  7 in total

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