J S Cunha Filho1, L F Terres, F Holanda, F Freitas, C Glitz, V K Genro, E Arbo. 1. Ob/Gyn depto., Hospital de Clínicas de Porto Alegre, Programa de Pós-graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, Porto Alegre, RS, CEP 90035-003, Brazil. sabino@via-rs.net
Abstract
PURPOSE: The purpose of the study was to compare the effectiveness of GnRH antagonist with luteal phase estradiol administration to GnRH agonist cycles, long protocol. METHODS: 55 IVF-ICSI patients received oestradiol in the luteal phase of the cycle, before a cycle with GnRH antagonist. Fifty-five patients submitted to IVF-ICSI with the use of agonist were allocated, age matched, as a control group (historical control). The primary outcome was the number of retrieved oocytes. RESULTS: Patients were similar in terms of clinical characteristics. No differences were found in the number of oocytes retrieved (study group, 8.1 +/- 4.7; control group, 7.4 +/- 4.5) or in oocyte quality. CONCLUSIONS: We clearly demonstrated that the effectiveness of GnRH antagonist when combined with luteal phase estradiol is comparable to GnRH agonist cycles.
PURPOSE: The purpose of the study was to compare the effectiveness of GnRH antagonist with luteal phase estradiol administration to GnRH agonist cycles, long protocol. METHODS: 55 IVF-ICSIpatients received oestradiol in the luteal phase of the cycle, before a cycle with GnRH antagonist. Fifty-five patients submitted to IVF-ICSI with the use of agonist were allocated, age matched, as a control group (historical control). The primary outcome was the number of retrieved oocytes. RESULTS:Patients were similar in terms of clinical characteristics. No differences were found in the number of oocytes retrieved (study group, 8.1 +/- 4.7; control group, 7.4 +/- 4.5) or in oocyte quality. CONCLUSIONS: We clearly demonstrated that the effectiveness of GnRH antagonist when combined with luteal phase estradiol is comparable to GnRH agonist cycles.
Authors: F Olivennes; J Belaisch-Allart; J C Emperaire; H Dechaud; S Alvarez; L Moreau; B Nicollet; J R Zorn; P Bouchard; R Frydman Journal: Fertil Steril Date: 2000-02 Impact factor: 7.329
Authors: C Albano; R E Felberbaum; J Smitz; H Riethmüller-Winzen; J Engel; K Diedrich; P Devroey Journal: Hum Reprod Date: 2000-03 Impact factor: 6.918
Authors: M Fluker; J Grifo; A Leader; M Levy; D Meldrum; S J Muasher; J Rinehart; Z Rosenwaks; R T Scott; W Schoolcraft; D B Shapiro Journal: Fertil Steril Date: 2001-01 Impact factor: 7.329
Authors: Renato Fanchin; João Sabino Cunha-Filho; Luca Maria Schonäuer; Isaac Jacques Kadoch; Paul Cohen-Bacri; René Frydman Journal: Fertil Steril Date: 2003-02 Impact factor: 7.329