Literature DB >> 17615169

Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.

E J Kim1, G D Rabinovici, W W Seeley, C Halabi, H Shu, M W Weiner, S J DeArmond, J Q Trojanowski, M L Gorno-Tempini, B L Miller, H J Rosen.   

Abstract

We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.

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Year:  2007        PMID： 17615169      PMCID： PMC2095621          DOI： 10.1136/jnnp.2006.114231

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


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