Literature DB >> 17609801

The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS).

Anatoly Chernyshev1, Todd Fleischmann, Eric M Koehn, Scott A Lesley, Amnon Kohen.   

Abstract

New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.

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Year:  2007        PMID： 17609801      PMCID： PMC4341948          DOI： 10.1039/b700977a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

1.  An alternative flavin-dependent mechanism for thymidylate synthesis.

Authors:  Hannu Myllykallio; Gerard Lipowski; Damien Leduc; Jonathan Filee; Patrick Forterre; Ursula Liebl
Journal:  Science       Date:  2002-05-23       Impact factor: 47.728

Review 2.  Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".

Authors:  Robert M Stroud; Janet S Finer-Moore
Journal:  Biochemistry       Date:  2003-01-21       Impact factor: 3.162

Review 3.  Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.

Authors:  Janet S Finer-Moore; Daniel V Santi; Robert M Stroud
Journal:  Biochemistry       Date:  2003-01-21       Impact factor: 3.162

4.  Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Authors:  Damien Leduc; Sébastien Graziani; Gerard Lipowski; Christophe Marchand; Pierre Le Maréchal; Ursula Liebl; Hannu Myllykallio
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-27       Impact factor: 11.205

5.  Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.

Authors:  Jonathon Griffin; Christine Roshick; Emma Iliffe-Lee; Grant McClarty
Journal:  J Biol Chem       Date:  2004-12-08       Impact factor: 5.157

6.  Phenol hydroxylase from yeast. Reaction with phenol derivatives.

Authors:  H Y Neujahr; K G Kjellén
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

7.  Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase.

Authors:  Samuel G Gattis; Bruce A Palfey
Journal:  J Am Chem Soc       Date:  2005-01-26       Impact factor: 15.419

8.  Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1.

Authors:  Sébastien Graziani; Yuannan Xia; James R Gurnon; James L Van Etten; Damien Leduc; Stéphane Skouloubris; Hannu Myllykallio; Ursula Liebl
Journal:  J Biol Chem       Date:  2004-10-06       Impact factor: 5.157

9.  A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases.

Authors:  M Zhou; Z Diwu; N Panchuk-Voloshina; R P Haugland
Journal:  Anal Biochem       Date:  1997-11-15       Impact factor: 3.365

10.  Mechanistic studies of a flavin-dependent thymidylate synthase.

Authors:  Nitish Agrawal; Scott A Lesley; Peter Kuhn; Amnon Kohen
Journal:  Biochemistry       Date:  2004-08-17       Impact factor: 3.162
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  8 in total

1.  Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.

Authors:  Tatiana V Mishanina; Eric M Koehn; John A Conrad; Bruce A Palfey; Scott A Lesley; Amnon Kohen
Journal:  J Am Chem Soc       Date:  2012-02-24       Impact factor: 15.419

2.  Flavin-dependent thymidylate synthase X limits chromosomal DNA replication.

Authors:  Frédéric Escartin; Stéphane Skouloubris; Ursula Liebl; Hannu Myllykallio
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-11       Impact factor: 11.205

Review 3.  Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.

Authors:  Kalani Karunaratne; Nicholas Luedtke; Daniel M Quinn; Amnon Kohen
Journal:  Arch Biochem Biophys       Date:  2017-08-15       Impact factor: 4.013

4.  Folate binding site of flavin-dependent thymidylate synthase.

Authors:  Eric M Koehn; Laura L Perissinotti; Salah Moghram; Arjun Prabhakar; Scott A Lesley; Irimpan I Mathews; Amnon Kohen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-10       Impact factor: 11.205

5.  Oxidase activity of a flavin-dependent thymidylate synthase.

Authors:  Zhen Wang; Anatoly Chernyshev; Eric M Koehn; Tony D Manuel; Scott A Lesley; Amnon Kohen
Journal:  FEBS J       Date:  2009-05       Impact factor: 5.542

6.  Flavin-dependent thymidylate synthase: a novel pathway towards thymine.

Authors:  Eric M Koehn; Amnon Kohen
Journal:  Arch Biochem Biophys       Date:  2009-07-28       Impact factor: 4.013

7.  Detection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation.

Authors:  John A Conrad; Mariliz Ortiz-Maldonado; Samuel W Hoppe; Bruce A Palfey
Journal:  Biochemistry       Date:  2014-08-08       Impact factor: 3.162

8.  Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.

Authors:  Tamara Basta; Yap Boum; Julien Briffotaux; Hubert F Becker; Isabelle Lamarre-Jouenne; Jean-Christophe Lambry; Stephane Skouloubris; Ursula Liebl; Marc Graille; Herman van Tilbeurgh; Hannu Myllykallio
Journal:  Open Biol       Date:  2012-10       Impact factor: 6.411
  8 in total

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