Literature DB >> 12525150

Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".

Robert M Stroud1, Janet S Finer-Moore.   

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Year:  2003        PMID： 12525150     DOI： 10.1021/bi020598i

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


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  42 in total

1.  Structure of the Y94F mutant of Escherichia coli thymidylate synthase.

Authors:  Sue A Roberts; David C Hyatt; Jerry E Honts; Liming Changchien; Gladys F Maley; Frank Maley; William R Montfort
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-08-18

2.  Hydride transfer versus hydrogen radical transfer in thymidylate synthase.

Authors:  Baoyu Hong; Majd Haddad; Frank Maley; Jan H Jensen; Amnon Kohen
Journal:  J Am Chem Soc       Date:  2006-05-03       Impact factor: 15.419

3.  The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS).

Authors:  Anatoly Chernyshev; Todd Fleischmann; Eric M Koehn; Scott A Lesley; Amnon Kohen
Journal:  Chem Commun (Camb)       Date:  2007-04-25       Impact factor: 6.222

4.  The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.

Authors:  Lydia M Gibson; Leslie L Lovelace; Lukasz Lebioda
Journal:  Biochemistry       Date:  2008-03-28       Impact factor: 3.162

5.  A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

Authors:  Zhen Wang; Thelma Abeysinghe; Janet S Finer-Moore; Robert M Stroud; Amnon Kohen
Journal:  J Am Chem Soc       Date:  2012-10-15       Impact factor: 15.419

6.  Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase.

Authors:  Baoyu Hong; Frank Maley; Amnon Kohen
Journal:  Biochemistry       Date:  2007-11-14       Impact factor: 3.162

7.  The general base in the thymidylate synthase catalyzed proton abstraction.

Authors:  Ananda K Ghosh; Zahidul Islam; Jonathan Krueger; Thelma Abeysinghe; Amnon Kohen
Journal:  Phys Chem Chem Phys       Date:  2015-12-14       Impact factor: 3.676

8.  5,10-Methylene-5,6,7,8-tetrahydrofolate conformational transitions upon binding to thymidylate synthase: molecular mechanics and continuum solvent studies.

Authors:  Adam Jarmuła; Piotr Cieplak; William R Montfort
Journal:  J Comput Aided Mol Des       Date:  2005-02       Impact factor: 3.686

Review 9.  Relationship of femtosecond-picosecond dynamics to enzyme-catalyzed H-transfer.

Authors:  Christopher M Cheatum; Amnon Kohen
Journal:  Top Curr Chem       Date:  2013

10.  Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Authors:  Zhen Wang; Paul J Sapienza; Thelma Abeysinghe; Calvin Luzum; Andrew L Lee; Janet S Finer-Moore; Robert M Stroud; Amnon Kohen
Journal:  J Am Chem Soc       Date:  2013-05-10       Impact factor: 15.419
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