Literature DB >> 17544228

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging.

Peter D Adams1.   

Abstract

Cellular senescence is an important tumor suppression process, and a possible contributor to tissue aging. Senescence is accompanied by extensive changes in chromatin structure. In particular, many senescent cells accumulate specialized domains of facultative heterochromatin, called Senescence-Associated Heterochromatin Foci (SAHF), which are thought to repress expression of proliferation-promoting genes, thereby contributing to senescence-associated proliferation arrest. This article reviews our current understanding of the structure, assembly and function of these SAHF at a cellular level. The possible contribution of SAHF to tumor suppression and tissue aging is also critically discussed.

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Year:  2007        PMID： 17544228      PMCID： PMC2755200          DOI： 10.1016/j.gene.2007.04.020

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  148 in total

1.  PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.

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Journal:  Nature       Date:  2000-07-13       Impact factor: 49.962

2.  PML is induced by oncogenic ras and promotes premature senescence.

Authors:  G Ferbeyre; E de Stanchina; E Querido; N Baptiste; C Prives; S W Lowe
Journal:  Genes Dev       Date:  2000-08-15       Impact factor: 11.361

3.  Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.

Authors:  C Costanzi; J R Pehrson
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

Review 4.  Replicative senescence: considerations relating to the stability of heterochromatin domains.

Authors:  B H Howard
Journal:  Exp Gerontol       Date:  1996 Jan-Apr       Impact factor: 4.032

5.  Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA.

Authors:  D A Hill; R Reeves
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

6.  Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

Authors:  H S Zhang; M Gavin; A Dahiya; A A Postigo; D Ma; R X Luo; J W Harbour; D C Dean
Journal:  Cell       Date:  2000-03-31       Impact factor: 41.582

7.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors:  M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal:  Cell       Date:  1997-03-07       Impact factor: 41.582

8.  BRG-1 is required for RB-mediated cell cycle arrest.

Authors:  M W Strobeck; K E Knudsen; A F Fribourg; M F DeCristofaro; B E Weissman; A N Imbalzano; E S Knudsen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

9.  Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle.

Authors:  M S Spector; A Raff; H DeSilva; K Lee; M A Osley
Journal:  Mol Cell Biol       Date:  1997-02       Impact factor: 4.272

10.  Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I.

Authors:  P D Kaufman; J L Cohen; M A Osley
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272
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  76 in total

1.  Global heterochromatin loss: a unifying theory of aging?

Authors:  Amy Tsurumi; Willis X Li
Journal:  Epigenetics       Date:  2012-07-01       Impact factor: 4.528

Review 2.  Inflammatory networks during cellular senescence: causes and consequences.

Authors:  Adam Freund; Arturo V Orjalo; Pierre-Yves Desprez; Judith Campisi
Journal:  Trends Mol Med       Date:  2010-05-03       Impact factor: 11.951

Review 3.  Epigenetic control of aging.

Authors:  Ursula Muñoz-Najar; John M Sedivy
Journal:  Antioxid Redox Signal       Date:  2010-11-22       Impact factor: 8.401

Review 4.  The essence of senescence.

Authors:  Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper
Journal:  Genes Dev       Date:  2010-11-15       Impact factor: 11.361

5.  A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Authors:  Katrin Tschöp; Andrew R Conery; Larisa Litovchick; James A Decaprio; Jeffrey Settleman; Ed Harlow; Nicholas Dyson
Journal:  Genes Dev       Date:  2011-04-15       Impact factor: 11.361

Review 6.  Chapter 5. Nuclear actin-related proteins in epigenetic control.

Authors:  Richard B Meagher; Muthugapatti K Kandasamy; Elizabeth C McKinney; Eileen Roy
Journal:  Int Rev Cell Mol Biol       Date:  2009       Impact factor: 6.813

Review 7.  Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence.

Authors:  Yingxi Xu; Na Li; Rong Xiang; Peiqing Sun
Journal:  Trends Biochem Sci       Date:  2014-05-09       Impact factor: 13.807

8.  Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence.

Authors:  Akira Tsujii; Yoichi Miyamoto; Tetsuji Moriyama; Yuko Tsuchiya; Chikashi Obuse; Kenji Mizuguchi; Masahiro Oka; Yoshihiro Yoneda
Journal:  J Biol Chem       Date:  2015-10-21       Impact factor: 5.157

Review 9.  Quality and quantity control of proteins in senescence.

Authors:  Masashi Narita
Journal:  Aging (Albany NY)       Date:  2010-05       Impact factor: 5.682

10.  Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases.

Authors:  Todd E Golde; Victor M Miller
Journal:  Alzheimers Res Ther       Date:  2009-10-12       Impact factor: 6.982
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