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Literature DB >> 17502415

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

William J Steinbach¹, Robert A Cramer, B Zachary Perfect, Christina Henn, Kirsten Nielsen, Joseph Heitman, John R Perfect.

Abstract

Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.

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Year: 2007 PMID： 17502415 PMCID： PMC1932494 DOI： 10.1128/AAC.01394-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients.

Authors: Kieren A Marr; Rachel A Carter; Fulvio Crippa; Anna Wald; Lawrence Corey
Journal: Clin Infect Dis Date: 2002-02-26 Impact factor: 9.079

2. Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.

Authors: David A Stevens; Masayuki Ichinomiya; Yukako Koshi; Hiroyuki Horiuchi
Journal: Antimicrob Agents Chemother Date: 2006-09 Impact factor: 5.191

3. Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.

Authors: D A Stevens
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

4. Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae.

Authors: L J García-Rodriguez; J A Trilla; C Castro; M H Valdivieso; A Durán; C Roncero
Journal: FEBS Lett Date: 2000-07-28 Impact factor: 4.124

5. In-vitro activity of nikkomycin Z alone and in combination with polyenes, triazoles or echinocandins against Aspergillus fumigatus.

Authors: L T Ganesan; E K Manavathu; J L Cutright; G J Alangaden; P H Chandrasekar
Journal: Clin Microbiol Infect Date: 2004-11 Impact factor: 8.067

6. Synergy, pharmacodynamics, and time-sequenced ultrastructural changes of the interaction between nikkomycin Z and the echinocandin FK463 against Aspergillus fumigatus.

Authors: C C Chiou; N Mavrogiorgos; E Tillem; R Hector; T J Walsh
Journal: Antimicrob Agents Chemother Date: 2001-12 Impact factor: 5.191

7. Synergistic action of nikkomycins X and Z with papulacandin B on whole cells and regenerating protoplasts of Candida albicans.

Authors: R F Hector; P C Braun
Journal: Antimicrob Agents Chemother Date: 1986-03 Impact factor: 5.191

8. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

Authors: M B Kurtz; I B Heath; J Marrinan; S Dreikorn; J Onishi; C Douglas
Journal: Antimicrob Agents Chemother Date: 1994-07 Impact factor: 5.191

9. Killing activity of micafungin against Aspergillus fumigatus hyphae assessed by specific fluorescent staining for cell viability.

Authors: Etsuko Watabe; Toru Nakai; Satoru Matsumoto; Fumiaki Ikeda; Kazuo Hatano
Journal: Antimicrob Agents Chemother Date: 2003-06 Impact factor: 5.191

10. The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro.

Authors: J C Bowman; P Scott Hicks; M B Kurtz; H Rosen; D M Schmatz; P A Liberator; C M Douglas
Journal: Antimicrob Agents Chemother Date: 2002-09 Impact factor: 5.191

53 in total

1. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.

Authors: Praveen Rao Juvvadi; Jarrod R Fortwendel; Luise E Rogg; Kimberlie A Burns; Scott H Randell; William J Steinbach
Journal: Mol Microbiol Date: 2011-11-08 Impact factor: 3.501

Review 2. Calcineurin regulation in fungi and beyond.

Authors: Jamal Stie; Deborah Fox
Journal: Eukaryot Cell Date: 2007-12-07

3. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.

Authors: Praveen Rao Juvvadi; Jarrod R Fortwendel; Nadthanan Pinchai; B Zachary Perfect; Joseph Heitman; William J Steinbach
Journal: Eukaryot Cell Date: 2008-07-07

4. The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Authors: Nadthanan Pinchai; Praveen Rao Juvvadi; Jarrod R Fortwendel; B Zachary Perfect; Luise E Rogg; Yohannes G Asfaw; William J Steinbach
Journal: Eukaryot Cell Date: 2010-01-22