Literature DB >> 18606829

Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.

Praveen Rao Juvvadi1, Jarrod R Fortwendel, Nadthanan Pinchai, B Zachary Perfect, Joseph Heitman, William J Steinbach.   

Abstract

A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus DeltacnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.

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Year:  2008        PMID： 18606829      PMCID： PMC2547068          DOI： 10.1128/EC.00200-08

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  29 in total

Review 1.  Calcineurin regulation in fungi and beyond.

Authors:  Jamal Stie; Deborah Fox
Journal:  Eukaryot Cell       Date:  2007-12-07

2.  Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.

Authors:  M C Cruz; D S Fox; J Heitman
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

3.  Functional characterization of the Aspergillus fumigatus calcineurin.

Authors:  Márcia Eliana da Silva Ferreira; Thorsten Heinekamp; Albert Härtl; Axel A Brakhage; Camile P Semighini; Steven D Harris; Marcela Savoldi; Paula Fagundes de Gouvêa; Maria Helena de Souza Goldman; Gustavo H Goldman
Journal:  Fungal Genet Biol       Date:  2006-09-20       Impact factor: 3.495

4.  Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.

Authors:  Robert A Cramer; B Zachary Perfect; Nadthanan Pinchai; Steven Park; David S Perlin; Yohannes G Asfaw; Joseph Heitman; John R Perfect; William J Steinbach
Journal:  Eukaryot Cell       Date:  2008-05-02

5.  Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Authors:  Frederico Marianetti Soriani; Iran Malavazi; Márcia Eliana da Silva Ferreira; Marcela Savoldi; Marcia Regina Von Zeska Kress; Maria Helena de Souza Goldman; Omar Loss; Elaine Bignell; Gustavo Henrique Goldman
Journal:  Mol Microbiol       Date:  2008-02-20       Impact factor: 3.501

6.  Calmodulin bound to stress fibers but not microtubules involves regulation of cell morphology and motility.

Authors:  Jun Yuan; Guo-Xin Shi; Yue Shao; Gu Dai; Jun-Ning Wei; Donald C Chang; Chao-Jun Li
Journal:  Int J Biochem Cell Biol       Date:  2007-08-12       Impact factor: 5.085

Review 7.  Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Authors:  Reinhard Fischer; Nadine Zekert; Norio Takeshita
Journal:  Mol Microbiol       Date:  2008-04-08       Impact factor: 3.501

Review 8.  Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

Authors:  William J Steinbach; Jennifer L Reedy; Robert A Cramer; John R Perfect; Joseph Heitman
Journal:  Nat Rev Microbiol       Date:  2007-06       Impact factor: 60.633

9.  Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

Authors:  William J Steinbach; Robert A Cramer; B Zachary Perfect; Christina Henn; Kirsten Nielsen; Joseph Heitman; John R Perfect
Journal:  Antimicrob Agents Chemother       Date:  2007-05-14       Impact factor: 5.191

Review 10.  Physiological roles of calcineurin in Saccharomyces cerevisiae with special emphasis on its roles in G2/M cell-cycle regulation.

Authors:  Tokichi Miyakawa; Masaki Mizunuma
Journal:  Biosci Biotechnol Biochem       Date:  2007-03-07       Impact factor: 2.043
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  23 in total

1.  Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.

Authors:  Praveen Rao Juvvadi; Jarrod R Fortwendel; Luise E Rogg; Kimberlie A Burns; Scott H Randell; William J Steinbach
Journal:  Mol Microbiol       Date:  2011-11-08       Impact factor: 3.501

2.  Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Authors:  Jarrod R Fortwendel; Praveen R Juvvadi; Luise E Rogg; William J Steinbach
Journal:  Eukaryot Cell       Date:  2011-01-28

3.  Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.

Authors:  Lukasz Kozubowski; Eanas F Aboobakar; Maria E Cardenas; Joseph Heitman
Journal:  Eukaryot Cell       Date:  2011-07-01

Review 4.  Developmental regulators in Aspergillus fumigatus.

Authors:  Hee-Soo Park; Jae-Hyuk Yu
Journal:  J Microbiol       Date:  2016-02-27       Impact factor: 3.422

Review 5.  Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Authors:  Praveen R Juvvadi; Soo Chan Lee; Joseph Heitman; William J Steinbach
Journal:  Virulence       Date:  2016-06-20       Impact factor: 5.882

Review 6.  Regulatory circuitry governing fungal development, drug resistance, and disease.

Authors:  Rebecca S Shapiro; Nicole Robbins; Leah E Cowen
Journal:  Microbiol Mol Biol Rev       Date:  2011-06       Impact factor: 11.056

7.  Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

Authors:  Frédéric Lamoth; Praveen R Juvvadi; Jarrod R Fortwendel; William J Steinbach
Journal:  Eukaryot Cell       Date:  2012-07-20

8.  Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.

Authors:  Praveen R Juvvadi; M Arthur Moseley; Christopher J Hughes; Erik J Soderblom; Sarah Lennon; Simon R Perkins; J Will Thompson; Scott J Geromanos; Jason Wildgoose; Keith Richardson; James I Langridge; Johannes P C Vissers; William J Steinbach
Journal:  J Proteome Res       Date:  2017-12-29       Impact factor: 4.466

9.  The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.

Authors:  Hilary Renshaw; José M Vargas-Muñiz; Praveen R Juvvadi; Amber D Richards; Greg Waitt; Erik J Soderblom; M Arthur Moseley; William J Steinbach
Journal:  J Cell Sci       Date:  2018-02-07       Impact factor: 5.285

Review 10.  Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.

Authors:  Praveen R Juvvadi; Frédéric Lamoth; William J Steinbach
Journal:  Mycopathologia       Date:  2014-08-15       Impact factor: 2.574
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