Literature DB >> 12760883

Killing activity of micafungin against Aspergillus fumigatus hyphae assessed by specific fluorescent staining for cell viability.

Etsuko Watabe1, Toru Nakai, Satoru Matsumoto, Fumiaki Ikeda, Kazuo Hatano.   

Abstract

We studied the anti-Aspergillus activity of micafungin by using two fluorescent dyes to detect cell viability. Micafungin induced flattened hyphae, caused by the bursting of cells, which had lost their viability. Micafungin has killing activity against actively growing hyphae, even though it is not fungicidal against the whole burden of Aspergillus fumigatus.

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Year:  2003        PMID： 12760883      PMCID： PMC155853          DOI： 10.1128/AAC.47.6.1995-1998.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Antifungal mechanism of FK463 against Candida albicans and Aspergillus fumigatus.

Authors:  Kazuo Hatano; Yoshihiko Morishita; Toru Nakai; Fumiaki Ikeda
Journal:  J Antibiot (Tokyo)       Date:  2002-02       Impact factor: 2.649

2.  Assessment of the effect of amphotericin B on the vitality of Candida albicans.

Authors:  R S Liao; R P Rennie; J A Talbot
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  Glucan synthase complex of Aspergillus fumigatus.

Authors:  A Beauvais; J M Bruneau; P C Mol; M J Buitrago; R Legrand; J P Latgé
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

4.  Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis.

Authors:  F Ikeda; Y Wakai; S Matsumoto; K Maki; E Watabe; S Tawara; T Goto; Y Watanabe; F Matsumoto; S Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

5.  Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis.

Authors:  S Matsumoto; Y Wakai; T Nakai; K Hatano; T Ushitani; F Ikeda; S Tawara; T Goto; F Matsumoto; S Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

Review 6.  Fluorescence microscopy methods for yeast.

Authors:  J R Pringle; R A Preston; A E Adams; T Stearns; D G Drubin; B K Haarer; E W Jones
Journal:  Methods Cell Biol       Date:  1989       Impact factor: 1.441

7.  Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells.

Authors:  D E Epps; M L Wolfe; V Groppi
Journal:  Chem Phys Lipids       Date:  1994-02       Impact factor: 3.329

8.  In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi.

Authors:  S Tawara; F Ikeda; K Maki; Y Morishita; K Otomo; N Teratani; T Goto; M Tomishima; H Ohki; A Yamada; K Kawabata; H Takasugi; K Sakane; H Tanaka; F Matsumoto; S Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

9.  The behavior of oxonol dyes in phospholipid dispersions.

Authors:  C L Bashford; B Chance; J C Smith; T Yoshida
Journal:  Biophys J       Date:  1979-01       Impact factor: 4.033

10.  Characterization of uptake and hydrolysis of fluorescein diacetate and carboxyfluorescein diacetate by intracellular esterases in Saccharomyces cerevisiae, which result in accumulation of fluorescent product.

Authors:  P Breeuwer; J L Drocourt; N Bunschoten; M H Zwietering; F M Rombouts; T Abee
Journal:  Appl Environ Microbiol       Date:  1995-04       Impact factor: 4.792
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  6 in total

1.  Liposomal amphotericin B and echinocandins as monotherapy or sequential or concomitant therapy in murine disseminated and pulmonary Aspergillus fumigatus infections.

Authors:  Jon A Olson; Ancy George; David Constable; Peter Smith; Richard T Proffitt; Jill P Adler-Moore
Journal:  Antimicrob Agents Chemother       Date:  2010-07-06       Impact factor: 5.191

2.  Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.

Authors:  William J Steinbach; Robert A Cramer; B Zachary Perfect; Christina Henn; Kirsten Nielsen; Joseph Heitman; John R Perfect
Journal:  Antimicrob Agents Chemother       Date:  2007-05-14       Impact factor: 5.191

3.  Application of fluorescent probes to study structural changes in Aspergillus fumigatus exposed to amphotericin B, itraconazole, and voriconazole.

Authors:  Madhurama Gangwar; Richard Cole; Rama Ramani; Daniel J Sheehan; Vishnu Chaturvedi
Journal:  Mycopathologia       Date:  2006-08       Impact factor: 3.785

4.  Micafungin in the treatment of invasive candidiasis and invasive aspergillosis.

Authors:  Nathan P Wiederhold; Jason M Cota; Christopher R Frei
Journal:  Infect Drug Resist       Date:  2009-01-12       Impact factor: 4.003

5.  Microcolony imaging of Aspergillus fumigatus treated with echinocandins reveals both fungistatic and fungicidal activities.

Authors:  Colin J Ingham; Peter M Schneeberger
Journal:  PLoS One       Date:  2012-04-19       Impact factor: 3.240

6.  Caspofungin for the treatment of immunocompromised and severely ill children and neonates with invasive fungal infections.

Authors:  Nathan P Wiederhold; Lydia A Herrera
Journal:  Clin Med Insights Pediatr       Date:  2012-06-07
  6 in total

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