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Literature DB >> 17457417

Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.

Sadagopan Krishnan¹, Eli G Hvastkovs, Besnik Bajrami, Ingela Jansson, John B Schenkman, James F Rusling.

Abstract

We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.

Entities: Chemical Species

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Year: 2007 PMID： 17457417 DOI： 10.1039/b703012f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

17 in total

Review 1. Contributions of human enzymes in carcinogen metabolism.

Authors: Slobodan Rendic; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2012-05-10 Impact factor: 3.739

2. High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

Authors: Linlin Zhao; John B Schenkman; James F Rusling
Journal: Anal Chem Date: 2010-11-19 Impact factor: 6.986

3. Thin film voltammetry of metabolic enzymes in rat liver microsomes.

Authors: Sadagopan Krishnan; James F Rusling
Journal: Electrochem commun Date: 2007-09 Impact factor: 4.724

Review 4. Biochemical applications of ultrathin films of enzymes, polyions and DNA.

Authors: James F Rusling; Eli G Hvastkovs; Dominic O Hull; John B Schenkman
Journal: Chem Commun (Camb) Date: 2007-08-30 Impact factor: 6.222

5. Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.

Authors: Minjeong So; John B Schenkman; James F Rusling
Journal: Chem Commun (Camb) Date: 2008-07-18 Impact factor: 6.222

Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.

Review 1. Contributions of human enzymes in carcinogen metabolism.

2. High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

3. Thin film voltammetry of metabolic enzymes in rat liver microsomes.

Review 4. Biochemical applications of ultrathin films of enzymes, polyions and DNA.

5. Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.

6. Electrochemiluminescence Arrays for Studies of Metabolite-related Toxicity.

7. Screening reactive metabolites bioactivated by multiple enzyme pathways using a multiplexed microfluidic system.

8. Synergistic metabolic toxicity screening using microsome/DNA electrochemiluminescent arrays and nanoreactors.

9. Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS.

10. Characterizing metabolic inhibition using electrochemical enzyme/DNA biosensors.