Literature DB >> 18802568

Electrochemical biosensor featuring a two-enzyme pathway and DNA for screening toxic reactive metabolites of arylamines.

Minjeong So1, John B Schenkman, James F Rusling.   

Abstract

We demonstrate for the first time a biosensor featuring a sequential two-enzyme pathway suitable to screen potentially toxic reactive metabolites generated during metabolism.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18802568      PMCID： PMC3715968          DOI： 10.1039/b805447a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  21 in total

1.  Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films.

Authors:  Liping Zhou; Jing Yang; Carmelita Estavillo; James D Stuart; John B Schenkman; James F Rusling
Journal:  J Am Chem Soc       Date:  2003-02-05       Impact factor: 15.419

Review 2.  Cytochromes P450 in the bioactivation of chemicals.

Authors:  Costas Ioannides; David F V Lewis
Journal:  Curr Top Med Chem       Date:  2004       Impact factor: 3.295

3.  Layer-by-layer arrangement by protein-protein interaction of sulfite oxidase and cytochrome c catalyzing oxidation of sulfite.

Authors:  Roman Dronov; Dirk G Kurth; Helmuth Möhwald; Roberto Spricigo; Silke Leimkühler; Ulla Wollenberger; K V Rajagopalan; Frieder W Scheller; Fred Lisdat
Journal:  J Am Chem Soc       Date:  2008-01-05       Impact factor: 15.419

4.  Monooxygenation of an aromatic ring by F43W/H64D/V68I myoglobin mutant and hydrogen peroxide. Myoglobin mutants as a model for P450 hydroxylation chemistry.

Authors:  Thomas D Pfister; Takahiro Ohki; Takafumi Ueno; Isao Hara; Seiji Adachi; Yumiko Makino; Norikazu Ueyama; Yi Lu; Yoshihito Watanabe
Journal:  J Biol Chem       Date:  2005-01-21       Impact factor: 5.157

Review 5.  DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.

Authors:  H A Schut; E G Snyderwine
Journal:  Carcinogenesis       Date:  1999-03       Impact factor: 4.944

6.  Evaluating enzymes that generate genotoxic benzo[a]pyrene metabolites using sensor arrays.

Authors:  Bingquan Wang; Ingela Jansson; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2005-03-01       Impact factor: 6.986

7.  Mass spectrometric detection and measurement of N2-(2'-deoxyguanosin-8-yl)PhIP adducts in DNA.

Authors:  S J Crosbie; S Murray; A R Boobis; N J Gooderham
Journal:  J Chromatogr B Biomed Sci Appl       Date:  2000-07-07

Review 8.  Sensors for toxicity of chemicals and oxidative stress based on electrochemical catalytic DNA oxidation.

Authors:  James F Rusling
Journal:  Biosens Bioelectron       Date:  2004-11-15       Impact factor: 10.618

9.  Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its N-hydroxy metabolite into rat pancreatic acini and hepatocytes in vitro.

Authors:  N J Butcher; R F Minchin; F F Kadlubar; K F Ilett
Journal:  Carcinogenesis       Date:  1996-04       Impact factor: 4.944

10.  Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

Authors:  D W Hein; M A Doll; T D Rustan; K Gray; Y Feng; R J Ferguson; D M Grant
Journal:  Carcinogenesis       Date:  1993-08       Impact factor: 4.944
View more
  2 in total

1.  Characterizing metabolic inhibition using electrochemical enzyme/DNA biosensors.

Authors:  Dominic O Hull; Besnik Bajrami; Ingela Jansson; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2009-01-15       Impact factor: 6.986

2.  Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Authors:  Linlin Zhao; John B Schenkman; James F Rusling
Journal:  Chem Commun (Camb)       Date:  2009-08-17       Impact factor: 6.222
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.