| Literature DB >> 17418911 |
Itay Tirosh1, Judith Berman, Naama Barkai.
Abstract
In Saccharomyces cerevisiae, transcription factor binding sites are found preferentially approximately 100-200 bp upstream of the start codon. Here, we show that this region is associated with rigid DNA in promoters lacking a TATA box, but not in TATA-containing promoters. The association of rigid DNA with transcription factor binding sites is conserved in TATA-less promoters from 11 yeast species, whereas the position of the rigid DNA varies substantially among species. Rigid DNA could influence nucleosome positioning and assist in the assembly of the transcriptional machinery at TATA-less promoters.Entities:
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Year: 2007 PMID： 17418911 DOI： 10.1016/j.tig.2007.03.015
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639