Literature DB >> 17409072

Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae.

Rebecca L Hurto1, Amy Hin Yan Tong, Charles Boone, Anita K Hopper.   

Abstract

Nuclear export of tRNA is an essential eukaryotic function, yet the one known yeast tRNA nuclear exporter, Los1, is nonessential. Moreover recent studies have shown that tRNAs can move retrograde from the cytosol to the nucleus by an undefined process. Therefore, additional gene products involved in tRNA nucleus-cytosol dynamics have yet to be identified. Synthetic genetic array (SGA) analysis was employed to identify proteins involved in Los1-independent tRNA transport and in regulating tRNA nucleus-cytosol distribution. These studies uncovered synthetic interactions between los1Delta and pho88Delta involved in inorganic phopsphate uptake. Further analysis revealed that inorganic phosphate deprivation causes transient, temperature-dependent nuclear accumulation of mature cytoplasmic tRNA within nuclei via a Mtr10- and retrograde-dependent pathway, providing a novel connection between tRNA subcellular dynamics and phosphate availability.

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Year:  2007        PMID： 17409072      PMCID： PMC1894612          DOI： 10.1534/genetics.106.069732

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  47 in total

1.  Genome-wide mRNA surveillance is coupled to mRNA export.

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2.  tRNA actively shuttles between the nucleus and cytosol in yeast.

Authors:  Akira Takano; Toshiya Endo; Tohru Yoshihisa
Journal:  Science       Date:  2005-05-19       Impact factor: 47.728

3.  The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus.

Authors:  A Kaffman; N M Rank; E M O'Neill; L S Huang; E K O'Shea
Journal:  Nature       Date:  1998-12-03       Impact factor: 49.962

4.  Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p.

Authors:  N Nakashima; E Noguchi; T Nishimoto
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

5.  Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

Authors:  E A Winzeler; D D Shoemaker; A Astromoff; H Liang; K Anderson; B Andre; R Bangham; R Benito; J D Boeke; H Bussey; A M Chu; C Connelly; K Davis; F Dietrich; S W Dow; M El Bakkoury; F Foury; S H Friend; E Gentalen; G Giaever; J H Hegemann; T Jones; M Laub; H Liao; N Liebundguth; D J Lockhart; A Lucau-Danila; M Lussier; N M'Rabet; P Menard; M Mittmann; C Pai; C Rebischung; J L Revuelta; L Riles; C J Roberts; P Ross-MacDonald; B Scherens; M Snyder; S Sookhai-Mahadeo; R K Storms; S Véronneau; M Voet; G Volckaert; T R Ward; R Wysocki; G S Yen; K Yu; K Zimmermann; P Philippsen; M Johnston; R W Davis
Journal:  Science       Date:  1999-08-06       Impact factor: 47.728

6.  Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae.

Authors:  A L Goldstein; J H McCusker
Journal:  Yeast       Date:  1999-10       Impact factor: 3.239

7.  Structure and function of the GTP binding protein Gtr1 and its role in phosphate transport in Saccharomyces cerevisiae.

Authors:  Jens O Lagerstedt; Ian Reeve; John C Voss; Bengt L Persson
Journal:  Biochemistry       Date:  2005-01-18       Impact factor: 3.162

8.  The role of exportin-t in selective nuclear export of mature tRNAs.

Authors:  G J Arts; S Kuersten; P Romby; B Ehresmann; I W Mattaj
Journal:  EMBO J       Date:  1998-12-15       Impact factor: 11.598

9.  Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing.

Authors:  H R Chen; T Y Tsao; C H Chen; W Y Tsai; L S Her; M M Hsu; S C Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

10.  Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.

Authors:  K Hellmuth; D M Lau; F R Bischoff; M Künzler; E Hurt; G Simos
Journal:  Mol Cell Biol       Date:  1998-11       Impact factor: 4.272
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  35 in total

1.  Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing.

Authors:  Iwona Karkusiewicz; Tomasz W Turowski; Damian Graczyk; Joanna Towpik; Nripesh Dhungel; Anita K Hopper; Magdalena Boguta
Journal:  J Biol Chem       Date:  2011-09-22       Impact factor: 5.157

Review 2.  tRNA biology charges to the front.

Authors:  Eric M Phizicky; Anita K Hopper
Journal:  Genes Dev       Date:  2010-09-01       Impact factor: 11.361

3.  Utp9p facilitates Msn5p-mediated nuclear reexport of retrograded tRNAs in Saccharomyces cerevisiae.

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Review 4.  Controlling translation via modulation of tRNA levels.

Authors:  Jeremy E Wilusz
Journal:  Wiley Interdiscip Rev RNA       Date:  2015-04-28       Impact factor: 9.957

5.  Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei.

Authors:  Alan C Kessler; Sneha S Kulkarni; Mellie J Paulines; Mary Anne T Rubio; Patrick A Limbach; Zdeněk Paris; Juan D Alfonzo
Journal:  RNA Biol       Date:  2017-11-03       Impact factor: 4.652

6.  Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex.

Authors:  Shawn C Chafe; Dev Mangroo
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7.  Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae.

Authors:  Emily B Kramer; Anita K Hopper
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8.  Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p.

Authors:  Jacqueline B Pierce; George van der Merwe; Dev Mangroo
Journal:  Eukaryot Cell       Date:  2013-12-02

Review 9.  Cellular dynamics of tRNAs and their genes.

Authors:  Anita K Hopper; Dave A Pai; David R Engelke
Journal:  FEBS Lett       Date:  2010-01-21       Impact factor: 4.124

10.  Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae.

Authors:  Athulaprabha Murthi; Hussam H Shaheen; Hsiao-Yun Huang; Melanie A Preston; Tsung-Po Lai; Eric M Phizicky; Anita K Hopper
Journal:  Mol Biol Cell       Date:  2009-12-23       Impact factor: 4.138
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