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Literature DB >> 15905365

tRNA actively shuttles between the nucleus and cytosol in yeast.

Akira Takano¹, Toshiya Endo, Tohru Yoshihisa.

Abstract

Previous evidence suggested that transfer RNAs (tRNAs) cross the nuclear envelope to the cytosol only once after maturing in the nucleus. We now present evidence for nuclear import of tRNAs in yeast. Several export mutants accumulate mature tRNAs in the nucleus even in the absence of transcription. Import requires energy but not the Ran cycle. These results indicate that tRNAs shuttle between the nucleus and cytosol.

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Year: 2005 PMID： 15905365 DOI： 10.1126/science.1113346

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

94 in total

Review 1. tRNA biology charges to the front.

Authors: Eric M Phizicky; Anita K Hopper
Journal: Genes Dev Date: 2010-09-01 Impact factor: 11.361

Review 2. Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast.

Authors: Anna Domanska; Joanna Kaminska
Journal: RNA Biol Date: 2015 Impact factor: 4.652

3. Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.

Authors: Weifeng Gu; Rebecca L Hurto; Anita K Hopper; Elizabeth J Grayhack; Eric M Phizicky
Journal: Mol Cell Biol Date: 2005-09 Impact factor: 4.272

tRNA actively shuttles between the nucleus and cytosol in yeast.

Review 1. tRNA biology charges to the front.

Review 2. Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast.

3. Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.

4. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.

5. Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation.

6. The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability.

Review 7. Controlling translation via modulation of tRNA levels.

Review 8. tRNAs: cellular barcodes for amino acids.

Review 9. How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.

10. Retrograde nuclear transport from the cytoplasm is required for tRNA^Tyr maturation in T. brucei.

tRNA actively shuttles between the nucleus and cytosol in yeast.

Review 1. tRNA biology charges to the front.

Review 2. Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast.

3. Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.

4. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.

5. Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation.

6. The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability.

Review 7. Controlling translation via modulation of tRNA levels.

Review 8. tRNAs: cellular barcodes for amino acids.

Review 9. How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.

10. Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei.

10. Retrograde nuclear transport from the cytoplasm is required for tRNA^Tyr maturation in T. brucei.