Literature DB >> 17346045

Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses.

Madan K Kharel1, Lili Zhu, Tao Liu, Jürgen Rohr.   

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Year:  2007        PMID： 17346045      PMCID： PMC2543133          DOI： 10.1021/ja0680515

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  18 in total

Review 1.  Modification of post-PKS tailoring steps through combinatorial biosynthesis.

Authors:  Uwe Rix; Carsten Fischer; Lily L Remsing; Jürgen Rohr
Journal:  Nat Prod Rep       Date:  2002-10       Impact factor: 13.423

2.  The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box.

Authors:  Uwe Rix; Chenchen Wang; Yihua Chen; Fredilyn M Lipata; Lily L Remsing Rix; Lisa M Greenwell; Leo C Vining; Keqian Yang; Jürgen Rohr
Journal:  Chembiochem       Date:  2005-05       Impact factor: 3.164

3.  Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase.

Authors:  Yi-Hua Chen; Chen-Chen Wang; Lisa Greenwell; Uwe Rix; Dirk Hoffmeister; Leo C Vining; Jürgen Rohr; Ke-Qian Yang
Journal:  J Biol Chem       Date:  2005-04-06       Impact factor: 5.157

4.  The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.

Authors:  R G Summers; E Wendt-Pienkowski; H Motamedi; C R Hutchinson
Journal:  J Bacteriol       Date:  1993-12       Impact factor: 3.490

5.  Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.

Authors:  Liru Wang; Robert L White; Leo C Vining
Journal:  Microbiology (Reading)       Date:  2002-04       Impact factor: 2.777

6.  The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

Authors:  Uwe Rix; Jianting Zheng; Lily L Remsing Rix; Lisa Greenwell; Keqian Yang; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2004-04-14       Impact factor: 15.419

7.  Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.

Authors:  Tao Liu; Carsten Fischer; Claus Beninga; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2004-10-06       Impact factor: 15.419

8.  Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.

Authors:  J Ye; M L Dickens; R Plater; Y Li; J Lawrence; W R Strohl
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

9.  The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.

Authors:  Carsten Fischer; Fredilyn Lipata; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2003-07-02       Impact factor: 15.419

10.  Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.

Authors:  Jin-Young Chung; Isao Fujii; Shigeharu Harada; Ushio Sankawa; Yutaka Ebizuka
Journal:  J Bacteriol       Date:  2002-11       Impact factor: 3.490
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  15 in total

1.  A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Authors:  Eita Sasaki; Yasushi Ogasawara; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

Review 2.  Cyclization of aromatic polyketides from bacteria and fungi.

Authors:  Hui Zhou; Yanran Li; Yi Tang
Journal:  Nat Prod Rep       Date:  2010-03-31       Impact factor: 13.423

3.  Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway.

Authors:  Nidhi Tibrewal; Theresa E Downey; Steven G Van Lanen; Ehesan Ul Sharif; George A O'Doherty; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2012-07-19       Impact factor: 15.419

4.  The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis.

Authors:  Nicholas Noinaj; Mary A Bosserman; M Alexandra Schickli; Grzegorz Piszczek; Madan K Kharel; Pallab Pahari; Susan K Buchanan; Jürgen Rohr
Journal:  J Biol Chem       Date:  2011-05-10       Impact factor: 5.157

5.  Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.

Authors:  Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr
Journal:  Org Lett       Date:  2010-06-18       Impact factor: 6.005

6.  Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters.

Authors:  Madan K Kharel; S Eric Nybo; Micah D Shepherd; Jürgen Rohr
Journal:  Chembiochem       Date:  2010-03-01       Impact factor: 3.164

Review 7.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

8.  Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.

Authors:  Felipe Lombó; Mohamed S Abdelfattah; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  Chembiochem       Date:  2009-01-26       Impact factor: 3.164

9.  GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis.

Authors:  Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr
Journal:  Chembiochem       Date:  2009-05-25       Impact factor: 3.164

10.  Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.

Authors:  Nidhi Tibrewal; Pallab Pahari; Guojun Wang; Madan K Kharel; Caleb Morris; Theresa Downey; Yanpeng Hou; Tim S Bugni; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2012-10-29       Impact factor: 15.419
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